par-1 Antibody

Code CSB-PA880015XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans par-1 Polyclonal antibody
Uniprot No.
Target Names
par-1
Alternative Names
par-1 antibody; H39E23.1 antibody; Serine/threonine-protein kinase par-1 antibody; EC 2.7.11.1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans par-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis. Involved in the establishment of neuronal polarity.
Gene References into Functions
  1. Phosphorylation of FEZ1 by par-1 regulates its function in presynaptic protein trafficking. PMID: 27247180
  2. The par-1 protein is a possible cooperation and involvement in postembryo lethality, developmental timing, as well as SNARE protein trafficking. PMID: 24192838
  3. DNA replication is asymmetrically regulated in the two-cell stage embryo and the PAR-4 and PAR-1 polarity proteins dampen DNA replication dynamics specifically in the posterior blastomere. PMID: 24841566
  4. activity at the cell cortex is critical for mediating cell shape changes, cell surface composition, or cell signaling during vulval morphogenesis PMID: 12490197
  5. The par-1 kinase plays a major role in the antero-posterier axis formation and germline determinants polarisation. PMID: 15182702

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Subcellular Location
Cytoplasm, cell cortex.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Tissue Specificity
Asymmetrically localized to the posterior of the zygote before mitotic division, then differentially distributed to the germline precursor cells (at protein level).
Database Links

KEGG: cel:CELE_H39E23.1

STRING: 6239.H39E23.1d

UniGene: Cel.6280

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