Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Rab6 Polyclonal antibody

Uniprot No.

O18334

Target Names

Rab6

Alternative Names

Rab6 antibody; wrt antibody; CG6601 antibody; Ras-related protein Rab6 antibody; Protein warthog antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Rab6 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regulating CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6. Necessary for proper development of bristle shafts of macrochaete and microchaete on the head, thorax and scutellum. Modulates Notch signaling. As a key regulator of vesicular traffic, plays a critical role in the regulation of actin organization and is required for normal rates of phagocytic uptake during phagocytosis involved in defense against viral and fungal infection.

Gene References into Functions

Rab6 regulates apical cargo trafficking from the trans-Golgi network to recycling endosomes in fly photoreceptors. PMID: 27116570
Rab6 is required for multiple apical transport pathways but not the basolateral transport pathway in Drosophila photoreceptors.Rab6 is essential for the trans-Golgi network-recycling endosome transport. PMID: 26890939
Novel molecular events in the regulation of phagocytosis of infecting viruses by Rab6. PMID: 22928698
Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis. PMID: 17329360
Rab6 localizes to Golgi and Golgi-derived membranes and interacts with BicD in establishing cell polarity during oogenesis. PMID: 17827179

Hide All

Subcellular Location

Golgi apparatus membrane. Cell junction, synapse. Perikaryon.

Protein Families

Small GTPase superfamily, Rab family

Tissue Specificity

Expressed in larval eye, wing and leg imaginal disks and in salivary gland. Expressed in the larval optic lobe, showing an enrichment in the neuropil. In the adult brain, expressed in photoreceptors and mushroom body.

Database Links

KEGG: dme:Dmel_CG6601

STRING: 7227.FBpp0079943

UniGene: Dm.4067

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA963996XA01DLU
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Rab6 Antibody

Product Details

Customer Reviews and Q&A

Target Background