RAD50 Antibody

1. Data demonstrate that the dimerization state of the Rad50 hook domain exerts diverse influences on Mre11 complex function. PMID: 25601756
2. cohesin loading at replication sites depends on the structural features of Rad50 that are important for bridging sister chromatids, including the CXXC hook domain and the length of the coiled-coil extensions PMID: 22885006
3. deletion of RAD50 may block the major pathway of nonhomologous integration into a non-repetitive chromosomal locus; Rad50 may be involved in facilitating nonhomologous integration of both ends of the integrating DNA into a single chromosomal locus PMID: 21512733
4. amino acid substitutions in the rad50 ATP binding domain have effects on DNA double strand break repair PMID: 15546877
5. The Mre11/Rad50/Xrs2 (MRX) complex is essential for joining of incompatible ends by non-homologous end-joining during DNA repair, and the adenosine triphosphate (ATP)-dependent activities of Rad50 are critical for this process. PMID: 16043424
6. Rad50 is required for the induction of recombination between homologous chromosomes in cells in the vegetative growth state upon exposure to methyl methanesulfonate. PMID: 17507781
7. The Rad50/Mre11/Xrs2 complex is responsible for rapid processing of most damaged ends into substrates that subsequently undergo recombinational repair. PMID: 19763170

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KEGG: sce:YNL250W

STRING: 4932.YNL250W