rcsB Antibody

Datasheet

Code	CSB-PA988005XA01ENV
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Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) rcsB Polyclonal antibody

Uniprot No.

P0DMC7

Target Names

rcsB

Alternative Names

rcsB antibody; b2217 antibody; JW2205 antibody; Transcriptional regulatory protein RcsB antibody; Capsular synthesis regulator component B antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) rcsB protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. The system regulates expression of numerous genes, including genes involved in colanic acid capsule synthesis, biofilm formation, cell division and outer membrane proteins synthesis. Also involved, with GadE, in control of glutamate-dependent acid resistance, and, with BglJ, in derepression of the cryptic bgl operon. The RcsB-BglJ activity is probably independent of RcsB phosphorylation.

Gene References into Functions

BglJ-RcsB activates leuO, while LeuO inhibits activation by BglJ-RcsB. Furthermore, LeuO activates expression of bglJ, which is likewise H-NS repressed. PMID: 27695690
The structure reveals important molecular details of phosphorylation-independent dimerization of RcsB and has implication for the formation of heterodimers. PMID: 27670836
The results of this study significantly broaden the role for RcsB in enterohaemorrhagic Escherichia coli virulence regulation. PMID: 23985143
BglJ-RcsB is a pleiotropic transcriptional activator that coordinates regulation with global regulators including CRP, LeuO and HNS. PMID: 24335284
Acetylation inhibits RcsB activity and that some of this inhibition acts through the acetylation of Lys-154. PMID: 23852870
RcsB-BglJ binds to the leuO promoter region and activates one of two leuO promoters. PMID: 22295907
RcsB is required for inducible acid resistance and acts at gadE-dependent and -independent promoters. PMID: 21571995
activation of gadA transcription requires a GAD box and binding of an RcsB/GadE heterodimer. PMID: 20189963
RcsB and RcsC inversely regulated the timing of flagellar biogenesis PMID: 16776655
Results show RcsB influences the piliation state by controlling fimB and fimE transcription. PMID: 17644608

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Protein Families

RcsB family

Database Links

KEGG: ecj:JW2205

STRING: 316385.ECDH10B_2375

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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rcsB Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background