rho Antibody

Code CSB-PA323222XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) rho Polyclonal antibody
Uniprot No.
Target Names
rho
Alternative Names
rho; Ve; CG1004; Protein rhomboid; Protein veinlet
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) rho protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor.
Gene References into Functions
  1. a rhomboid enhancer element that selectively labels four Drosophila embryonic neural precursors, was characterized. PMID: 26252385
  2. Structure and mechanism of rhomboid protease. PMID: 23585569
  3. analysis of EGFR-dependent network interactions that pattern Drosophila eggshell appendages; each appendage is derived from a primordium comprising a patch of cells expressing broad (br) and an adjacent stripe of cells expressing rhomboid (rho) PMID: 22782725
  4. Drosophila RHO is the founder member of a previously undescribed family of serine proteases, and could be directly responsible for the unusual, intramembranous cleavage of EGFr ligands. PMID: 12221285
  5. A key component of mitochondrial fusion, Mgm1p, is activated by a novel mitochondrial endopeptidase related to this Drosophila melanogaster signaling protein. PMID: 12776123
  6. Substrate specificity of RHO intramembrane protease is governed by helix-breaking residues in the transmembrane domain. PMID: 12820957
  7. Evolution of the trans-regulatory environment that controls rho expression in somatic follicle cells could be a major contributor to the evolutionary changes in DA number. PMID: 17360774
  8. rhomboid may function in R8 cells to activate Epidermal growth factor receptor signaling in R7 cells PMID: 19261861

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Subcellular Location
Golgi apparatus membrane; Multi-pass membrane protein.
Protein Families
Peptidase S54 family
Database Links

KEGG: dme:Dmel_CG1004

STRING: 7227.FBpp0305409

UniGene: Dm.808

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