Sos Antibody

1. data support a model in which Robo's ligand-dependent internalization from cell surface to late endosome is essential for receptor activation and proper repulsive guidance at the midline by allowing recruitment of the downstream effector Son of Sevenless PMID: 26335920
2. identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris PMID: 25099352
3. Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1). PMID: 12673197
4. SosM98, an allele with a single amino acid substitution in the RacGEF motif, functions as a dominant negative in vivo to downregulate receptor tyrosine kinase signaling. PMID: 15286999
5. These results provide in vivo evidence that the Ras and RhoGEF domains of Sos are separable signaling modules and support a model in which Robo recruits Sos to the membrane via Dock to activate Rac during midline repulsion. PMID: 17114045

Show More

Hide All

KEGG: dme:Dmel_CG7793

STRING: 7227.FBpp0080118