SPP1 Antibody

1. A model where Spp1 works in three ways to promote recombination initiation: first by depositing histone H3K4 methylation (Set1 complex), next by "reading" and protecting histone H3K4 methylation, and finally by making the link with the chromosome axis (Mer2-Spp1 complex). This work deciphers the precise roles of Spp1 in meiotic recombination. PMID: 29444071
2. Spp1 regulates the catalytic activity of the enzyme (Set1) and mediates its biological effect (meiotic DSB formation) independently of the single Set1 Complex. PMID: 23511748
3. Spp1, a conserved member of the histone H3K4 methyltransferase Set1 complex, is required for normal levels of double strand breaks formation and is associated with chromosome axes during meiosis. PMID: 23246437
4. findings show tethering of Spp1 (a component of the COMPASS complex), to recombinationally cold regions is sufficient to induce double-strand breaks (DSB); by interacting with H3K4me3 and Mer2, Spp1 promotes recruitment of potential meiotic DSB sites to the chromosomal axis PMID: 23160953
5. the origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae PMID: 18845545
6. Data show that Tyr1052, a putative Phe/Tyr switch of Set1, plays an essential role in the regulation of H3K4 trimethylation by COMPASS and that the mutation to phenylalanine (Y1052F) suppresses the loss of Cps40 in H3K4 trimethylation levels. PMID: 19398585

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KEGG: sce:YPL138C

STRING: 4932.YPL138C