SPR Antibody

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Code	CSB-PA022605ZA01HU
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPR Polyclonal antibody

Uniprot No.

P35270

Target Names

SPR

Alternative Names

OTTHUMP00000160199 antibody; SDR38C1 antibody; Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase) antibody; Sepiapterin reductase antibody; Short chain dehydrogenase/reductase family 38C, member 1 antibody; SPR antibody; SPRE_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens

Immunogen

Recombinant Homo sapiens SPR protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

Gene References into Functions

The allele frequencies for the SPR c.596-2A > G (0.7%) polymorphism is not a major cause of Parkinson's disease in the Maltese. PMID: 27613114
We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma cell proliferation. PMID: 26093909
new homozygous mutation in the SPR gene was found in two sisters with dopa-responsive dystonia PMID: 24588500
Authors identified SPR as a novel regulator of ODC enzyme activity and, based on clinical evidence, present a model in which SPR drives ODC-mediated malignant progression in neuroblastoma. PMID: 24096079
SPR-mediated reduction of sepiapterin and redox cycling occur by distinct mechanisms PMID: 23640889
SRD can manifest as early-onset parkinsonism, widening the spectrum of the disease phenotype and adding to the genetic heterogeneity of the disease PMID: 22018912
this large association study for the SPR gene revealed no association for Parkinson disease worldwide. PMID: 21782285
We examine the sleep, sleep-wake rhythms, CSF neurotransmitters, and melatonin profile in a patient with sepiapterin reductase deficiency. PMID: 20337188
haploinsufficiency of SPR can be a rare cause of dopa-responsive dystonia PMID: 15241655
Potentially modulates the onset of or risk for Parkinson's disease. PMID: 16443856
Although association of SPR to Parkinson's disease (PD) is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD. PMID: 17270157
Genomic DNA revealed the same homozygous point mutation introducing a premature stop codon in the SPR gene in 2 siblings. PMID: 18502672
This reduced transcription rate for SPR promoter haplotypes 2 and 3 may impact on antidepressant response and susceptibility to bipolar disorder. PMID: 19415819

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Involvement in disease

Dystonia, DOPA-responsive, due to sepiapterin reductase deficiency (DRDSPRD)

Subcellular Location

Cytoplasm.

Protein Families

Sepiapterin reductase family

Database Links

HGNC: 11257

OMIM: 182125

KEGG: hsa:6697

STRING: 9606.ENSP00000234454

UniGene: Hs.301540

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SPR Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background