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Uniprot No.Target NamesSPRAlternative NamesOTTHUMP00000160199 antibody; SDR38C1 antibody; Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase) antibody; Sepiapterin reductase antibody; Short chain dehydrogenase/reductase family 38C, member 1 antibody; SPR antibody; SPRE_HUMAN antibodyRaised inRabbitSpecies ReactivityHuman,Mouse,RatImmunogenHuman SPRImmunogen SpeciesHomo sapiens (Human)IsotypeIgGPurification MethodAntigen Affinity purifiedConcentrationIt differs from different batches. Please contact us to confirm it.BufferPBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.Tested ApplicationsELISA,WB,IFTroubleshooting and FAQsStorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.Lead TimeBasically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.UsageFor Research Use Only. Not for use in diagnostic or therapeutic procedures.Related Products
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Target Background
FunctionCatalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.Gene References into Functions- The allele frequencies for the SPR c.596-2A > G (0.7%) polymorphism is not a major cause of Parkinson's disease in the Maltese. PMID: 27613114
- We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma cell proliferation. PMID: 26093909
- new homozygous mutation in the SPR gene was found in two sisters with dopa-responsive dystonia PMID: 24588500
- Authors identified SPR as a novel regulator of ODC enzyme activity and, based on clinical evidence, present a model in which SPR drives ODC-mediated malignant progression in neuroblastoma. PMID: 24096079
- SPR-mediated reduction of sepiapterin and redox cycling occur by distinct mechanisms PMID: 23640889
- SRD can manifest as early-onset parkinsonism, widening the spectrum of the disease phenotype and adding to the genetic heterogeneity of the disease PMID: 22018912
- this large association study for the SPR gene revealed no association for Parkinson disease worldwide. PMID: 21782285
- We examine the sleep, sleep-wake rhythms, CSF neurotransmitters, and melatonin profile in a patient with sepiapterin reductase deficiency. PMID: 20337188
- haploinsufficiency of SPR can be a rare cause of dopa-responsive dystonia PMID: 15241655
- Potentially modulates the onset of or risk for Parkinson's disease. PMID: 16443856
- Although association of SPR to Parkinson's disease (PD) is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD. PMID: 17270157
- Genomic DNA revealed the same homozygous point mutation introducing a premature stop codon in the SPR gene in 2 siblings. PMID: 18502672
- This reduced transcription rate for SPR promoter haplotypes 2 and 3 may impact on antidepressant response and susceptibility to bipolar disorder. PMID: 19415819
Involvement in diseaseDystonia, DOPA-responsive, due to sepiapterin reductase deficiency (DRDSPRD)Subcellular LocationCytoplasm.Protein FamiliesSepiapterin reductase familyDatabase Links
Email: [email protected]
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