beta-Spec Antibody

Datasheet

Code	CSB-PA251598XA01DLU
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes: beta-Spec Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 35.4 kDa Observed band size: 35.4 kDa
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Product Details

Uniprot No.

Q00963

Target Names

beta-Spec

Alternative Names

Spectrin beta chain beta-Spec Spec-b CG5870

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) beta-Spec protein (1-271aa)

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The beta-Spec polyclonal antibody is developed by administering a recombinant Drosophila melanogaster (Fruit fly) beta-Spec protein segment (1-271aa) to a rabbit. Several repeated immunizations trigger an immune response in the rabbit. The rabbit serum is extracted and then undergoes affinity chromatography purification to obtain polyclonal antibodies against beta-Spec. The beta-Spec antibody is suitable for the detection of the Drosophila melanogaster (Fruit fly) beta-Spec protein through ELISA and WB assays.

The beta-Spec protein in Drosophila melanogaster serves as a fundamental component of the cell cytoskeleton, contributing to the maintenance of cell shape, structural integrity, and membrane stability. As part of the spectrin family, beta-Spec plays diverse roles, including facilitating cell adhesion and migration, mediating intracellular transport, and influencing the proper localization of membrane proteins and organelles. In neurons, beta-Spec is crucial for the formation and maintenance of the axon initial segment.

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Target Background

Function

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Interacts with calmodulin in a calcium-dependent manner.

Gene References into Functions

The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the b-spectrin mutations and the loss of the Hippo signaling activity phenotype. PMID: 25589787
Model in which alphabeta-spectrin directly couples lipid uptake at the plasma membrane to lipid droplet growth in the cytoplasm. In contrast, strong overexpression of beta-spectrin caused fat body atrophy and larval lethality. PMID: 24037266
Data show that DAnk2-binding is critical for beta spectrin function in vivo. PMID: 20573981
Spectrin may be an active partner in the stabilization of polarized membrane domains PMID: 14734656
Presynaptic spectrin functions as an essential presynaptic scaffold that may link synaptic cell adhesion with the stabilization of the underlying microtubule cytoskeleton. PMID: 15916948
Brush border spectrin is required for early endosome recycling. PMID: 16537648
At the Drosophila neuromuscular junction postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged. PMID: 17088429
beta-Spectrin is required in neurons for proper midline axon guidance in the embryonic CNS. PMID: 17121810

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Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.

Protein Families

Spectrin family

Database Links

KEGG: dme:Dmel_CG5870

STRING: 7227.FBpp0074228

UniGene: Dm.7022

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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beta-Spec Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background