strm-1 Antibody

Code CSB-PA154165XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans strm-1 Polyclonal antibody
Uniprot No.
Target Names
strm-1
Alternative Names
strm-1 antibody; H14E04.1 antibody; Sterol 4-C-methyltransferase strm-1 antibody; EC 2.1.1.- antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans strm-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of the A-ring sterols such as lathosterone (5alpha-cholest-7-en-3-one) thereby rendering them unsuitable as ligand precursors. May irreversibly shunt sterols away from hormone dafachronic acid production. Dafachronic acids act as ligands and bind directly to the nuclear hormone receptor (NHR) daf-12 suppressing dauer formation and inducing reproductive growth. By reducing the biosynthesis of dafachronic acids, this methyltransferase can regulate dauer larva formation.
Gene References into Functions
  1. A methyltransferase, STRM-1, that modulates dafachronic acid levels and thus dauer formation, was identified. PMID: 19531354
Protein Families
Class I-like SAM-binding methyltransferase superfamily, Erg6/SMT family
Tissue Specificity
Expressed in the pharynx and hypodermal syncytium.
Database Links

KEGG: cel:CELE_H14E04.1

STRING: 6239.H14E04.1

UniGene: Cel.19957

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