Stxbp1 Antibody

1. SFK-dependent Munc18-1 phosphorylation may constitute a potent, previously unknown mechanism to shut down synaptic transmission, via direct occlusion of a Synaptobrevin/VAMP2 binding groove and subsequent hindrance of conformational changes in domain 3a responsible for vesicle priming. PMID: 29150433
2. This study demonstrated that the disruption of Munc18-1 function may result in the abnormal corticogenesis, leading to neurodevelopmental disorders with MUNC18-1 gene abnormalities. PMID: 29191246
3. Findings suggest that synaptic impairments of the dorsal telencephalic and subcortical excitatory neurons cause learning deficits and enhanced aggression in Stxbp1+/- mice, respectively. PMID: 29040524
4. This results of study concluded that a conformational change within helix 12 is responsible for the essential postdocking role of Munc18-1 in neurosecretion. PMID: 27358447
5. M18L was localized to presynaptic inhibitory terminals, and was associated with cognitive function and protection from dementia in an elderly PMID: 26628003
6. In this studying the Munc18-1-/- nervous system, we demonstrate that synaptic activity is dispensable for the early formation of spinal motor circuits at the levels of axon guidance, differentiation of transcriptional identity, and mRNA expression. PMID: 26758845
7. Vamp2 mutations that impair Munc18-1 binding inhibit spontaneous as well as evoked neurotransmitter release, providing evidence for the Vamp2-regulating function of Munc18-1 in synaptic exocytosis. PMID: 26572858
8. A dynamic PKC phosphorylation/de-phosphorylation cycle of Munc18-1 drives short-term enhancement of transmitter release during post-tetanic potentiation. PMID: 24520164
9. miR-218 and miR-322 directly interact with Stxbp1 by targeting the 3'UTR of its mRNA. PMID: 25489007
10. Heart rate results indicate enhanced conditioned fear in munc-18-1HZ mice PMID: 24304718
11. Munc18-1 levels correlate with synaptic strength. PMID: 24590174
12. Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation. PMID: 23484036
13. [review] Regulation of cortical F-actin is a shared function of Sec1/Munc18-like proteins; a way to gain more insight in the molecular mechanism underlying the Munc18-1-mediated cortical F-actin regulation is proposed. PMID: 22535313
14. SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1. PMID: 22810233
15. a novel indirect role for Munc18-1 in facilitating syntaxin 4-mediated granule pre-docking to support first-phase insulin exocytosis. PMID: 22685295
16. Munc18-1 and Munc18-2 display distinct subcellular compartmentalization and can coordinate the insulin exocytotic process differently as a consequence of the actual [Ca(2+)](i). PMID: 21690086
17. Dletion of Munc18-1 in 5-HT (serotonin) results in rapid degeneration of the 5-HT system. PMID: 22140524
18. Munc18, but not Munc13, regulates growth cone filopodia, potentially via its previously observed effect on filamentous actin. PMID: 20497124
19. Munc18-1 activates a SNARE complex with the typical configuration, in which each of the SNARE core domains is individually rooted in the membrane bilayer. PMID: 20603329
20. in the absence of presynaptic secretion immature synapses with a normal morphology form, but fewer in number in munc18-1 deficient mice PMID: 15145078
21. Morphological and immunohistological analysis of the hypothalamo-neurohypophysial system in munc18-1 nul mutant embryos during brain development showed that this peptidergic system was formed normally during early embryogenesis. PMID: 15182301
22. The lack of synaptic activity cannot explain the degeneration in munc18-1-null mutants. Second, trophic support delays but cannot prevent degeneration. PMID: 15255974
23. this study provides supporting evidence for the involvement of Stxbp1 in ethanol preference drinking PMID: 15897714
24. Munc18-1 is involved in the secretion of peptide hormones and in the docking of large dense-core vesicles PMID: 15898951
25. Munc18-1 either controls the spatially correct assembly of core complexes for SNARE-dependent fusion, or acts as a direct component of the fusion machinery itself. PMID: 15935055
26. Docking vesicles either undock immediately or are captured by minimal tethering machinery and converted in a munc18-1/syntaxin-dependent, strongly tethered, fusion-competent state. PMID: 16902411
27. number of vesicles docked at the active zone and the total number of vesicles per terminal correlated with both munc18-1 expression levels and the size of the releasable vesicle pool PMID: 17110441
28. Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein. PMID: 19170253
29. Munc18-1 binding to SNARE complexes mediates synaptic vesicle priming; the resulting primed state involves a Munc18-1-SNARE-complexin macromolecular assembly that is poised for Ca(2+) triggering of fusion. PMID: 19255244
30. show that presynaptic metabotropic glutamate receptors (mGluRs) bind and release Munc18-1 in a Ca(2+)-dependent manner, whose actions decrease and increase synaptic vesicle release, respectively. PMID: 19822743

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KEGG: mmu:20910

STRING: 10090.ENSMUSP00000089051

UniGene: Mm.278865