Sufu Antibody

1. Together, our results show that SuFu promotes cerebellar radial precursor differentiation to neurons. SuFu function is mediated in part by GLI3R and down-regulation of Fgf15 expression. PMID: 28560839
2. beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu. PMID: 29515120
3. Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. PMID: 28945232
4. tissue development is differentially affected in response to the reduced SUFU levels. PMID: 28688895
5. Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development PMID: 28794157
6. Thus, we provide evidence that Sufu is involved in the genetic network that restricts the posterior expression of Gli2/3/Hand2 and Gremlin/Fgf in limb bud patterning. PMID: 26001200
7. Results showed that the Thr396 residue of Sufu is specifically required for regulation of Gli3 but not Gli2 implying a novel Sufu-mediated mechanism in which Gli2 activator and Gli3 repressor are differentially regulated. PMID: 25760946
8. findings demonstrate that perturbations of Sufu and Kif7 affect Gli activity and recapitulate the full spectrum of vertebrate limb defects, ranging from severe truncation to polydactyly. PMID: 25581370
9. Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the nucleus, highlighting critical functions of Sufu in the nucleus. PMID: 25403183
10. Data suggest nuclear entry of GLI1 (glioma-associated oncogene homolog, a zinc finger protein) is regulated by unique mechanism via mutually exclusive binding by its nuclear import factor IMB1 (importin B1) and SuFu (suppressor of fused protein). PMID: 24854174
11. Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. PMID: 24886827
12. Evc silencing in Sufu(-/-) cells attenuated the output of the Hh pathway, suggesting that Evc/Evc2 also promote Hh signaling in the absence of Sufu PMID: 23026747
13. Sufu acts universally as a negative regulator of Hedgehog signaling. PMID: 23166838
14. These studies establish Sufu and Kif7 as crucial components in the regulation of Gli2 localization and activity, and illustrate their overlapping functions in skin development and tumor suppression. PMID: 23034632
15. Pthlh regulates chondrocyte differentiation and Gli activity in a Sufu-dependent manner, with Sufu acting as a molecular switch in its regulation of differentiation. PMID: 22930757
16. mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant PMID: 22666390
17. Sufu plays a positive role in the maximal activation of Hh signaling that defines the ventral-most cell fate in the mammalian spinal cord, likely through protecting Gli2 and Gli3 proteins from degradation. PMID: 22182519
18. Kif7 regulates the activity of Gli transcription factors through both Sufu-dependent and -independent mechanisms. PMID: 21795282
19. Glis3 interacts with Suppressor of Fused (SUFU) PMID: 21543335
20. ciliary localization of Sufu is dependent on ciliary-localized Gli proteins, and is inhibited by PKA activation PMID: 21209912
21. Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium. PMID: 21317289
22. Data demonstrate that SuFu controls cerebellar patterning and cell differentiation in a GLI3 repressor-dependent manner. PMID: 21289193
23. interaction between Gli3 and Suppressor of Fused (Sufu) regulates the formation of either repressor or activator forms of Gli3 PMID: 20360384
24. Suppressor of fused (Sufu) binds directly to SAP18, galectin3 and other nuclear proteins. PMID: 14611647
25. Targeted disruption of the murine suppressor of fused gene (Sufu) led to a phenotype that included neural tube and cardiac defects. PMID: 16155214
26. Su(fu) regulates the activity of Gli1 and Gli2 through distinct cytoplasmic and nuclear mechanisms PMID: 16316410
27. Sufu has a central role, and its loss of function leads to potent ligand-independent activation of the Hh pathway. PMID: 16459298
28. These results strongly suggest that GSK3beta phosphorylates Sufu to positively regulate Hedgehog signaling in mammalian cells. PMID: 17182001
29. studied tumor development in Sufu(+/-)Ptch1(+/-) mice to determine the effect of compound heterozygosity on the onset, incidence, and spectrum of tumors PMID: 18781608
30. Removal of Sufu in both Smoothened (Smo) and Ift88 mutants, respectively, leads to full activation of Hh signaling, suggesting that Smo-mediated repression of Sufu, but not the inhibitory function of Sufu, requires cilia PMID: 19371734
31. Sufu presumably functions as a GSK3beta recruiter for Hh-dependent regulation of Gli3 processing. PMID: 19622347
32. mouse Suppressor of fused (Sufu) regulates the stability of the transcription factors Gli2 and Gli3 by antagonizing the conserved Gli degradation device mediated by Hib/Spop in a cilia-independent manner PMID: 19684109
33. Sufu regulates Gli protein levels by antagonizing the activity of Spop, a conserved Gli-degrading factor PMID: 19684112

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KEGG: mmu:24069

STRING: 10090.ENSMUSP00000107498

UniGene: Mm.41210