Scg3 Antibody

Code CSB-PA020809ZA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Scg3 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Secretogranin-3 (1B1075) (Secretogranin III) (SgIII), Scg3
Raised in
Species Reactivity
Rattus norvegicus
Recombinant Rattus norvegicus Scg3 protein
Immunogen Species
Rattus norvegicus (Rat)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.
Gene References into Functions
  1. SgIII directly binds to cholesterol components of the secretory granule membrane and targets chromogranin A to secretory granules in pituitary and pancreatic endocrine cells PMID: 14597614
  2. SgIII is closely associated with the secretory granule membrane, serving to anchor the aggregates of other soluble constituents to the membrane. PMID: 15125023
  3. A small amount of secretogranin III is able to sort chromogranin A aggregates together with adrenomedullin to secretory granules. PMID: 18483175
  4. In mast cells, a secretogranin III-chromogranin A complex may play a key role in secretory granule biogenesis. PMID: 18802106
Subcellular Location
Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted.
Tissue Specificity
Expression restricted to the brain and pituitary gland. Not detected in the adrenal gland.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
7505 Fannin St Ste 610-322 Houston, TX 77054, USA
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