Sncb Antibody

1. the expression patterns of neuronal maturation markers in the brain of a mouse model of dementia with Lewy body-linked mutant beta-synuclein (betaS), especially in the hippocampus. PMID: 29976232
2. These results suggest that synucleins are important orchestrators of presynaptic terminal topography. PMID: 28052246
3. Immunoblot analysis of beta-synuclein and Akt levels in the mice reveals selective increases in beta-synuclein and phosphorylated Akt levels in ventral midbrain PMID: 21304957
4. Synuclein-alpha, -beta, and -gamma are important in regulating neurotransmitter release from specific populations of midbrain dopamine neurons through mechanisms that differ from those reported in other neurons. PMID: 21593311
5. late onset phenotypes in synuclein null mice were not due to a loss of synapses or neurons but rather reflect specific changes in synaptic protein composition and axonal structure PMID: 20974939
6. Beta-synuclein decreased formation of Lewy bodies by 40%, and prevented functional deficits associated with overexpression of alpha-synuclein. This is a preliminary in vivo proof of antiaggregatory function of beta-synuclein. PMID: 12212795
7. Accelerated accumulation of beta-synuclein is found in axonal spheroids of gracile axonal dystrophy mice, which do not express ubiquitin carboxyl-terminal hydrolase L1. PMID: 15306232
8. beta-synuclein knockout mice show that synucleins are not essential components of the basic machinery for neurotransmitter release but may contribute to the long-term regulation and/or maintenance of presynaptic function. PMID: 15465911
9. Developmentally, gamma-synuclein can be seen in the region of the outer hair cells by E19, while alpha- and beta-synuclein do not clearly appear there until approximately P10 PMID: 18665422

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KEGG: mmu:104069

STRING: 10090.ENSMUSP00000043074

UniGene: Mm.200843