Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Ten-m Polyclonal antibody

Uniprot No.

O61307

Target Names

Ten-m

Alternative Names

Ten-m antibody; odz antibody; CG5723 antibody; Teneurin-m antibody; Tenm antibody; Odd Oz protein antibody; Tenascin-like protein antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Ten-m protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre-synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also required for peripheral axon growth cone guidance and target recognition of motor neurons.

Gene References into Functions

Ten-m/Odz may have had an ancient role in cell-cell communication, parallel to the Notch and wnt pathways. The Ten-m protein binds to the membrane with properties which resemble other membrane-based biochemical oscillators. The oscillatory properties of Ten-m may play a seminal role in arthropod segmentation. PMID: 28461810
Ten-m acts in projection neurons autonomously to regulate acetylcholine receptor cluster number and transsynaptically to regulate olfactory receptor neurons active zone number. PMID: 25310239
Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells. PMID: 21857973
The structure and membrane orientation of this large enigmatic protein was characterized by raising and employing antibodies directed against discrete Odz polypeptide regions. PMID: 11964164
the odz gene is required for multiple cell types in the compound retina PMID: 17685476

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Subcellular Location

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, synaptosome. Membrane; Single-pass membrane protein. Note=Localizes at neuromuscular junction. Localizes in neuron cell bodies. Colocalizes with alpha-Spec at the membranous subsynaptic reticulum (SSR).

Protein Families

Tenascin family, Teneurin subfamily

Tissue Specificity

Expressed in muscles and motor neurons (at protein level).

Database Links

KEGG: dme:Dmel_CG5723

STRING: 7227.FBpp0303192

UniGene: Dm.2499

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Ten-m Antibody

Product Details

Customer Reviews and Q&A

Target Background