TMPRSS11A Antibody

Code CSB-PA757932ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TMPRSS11A Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Epidermal type-II transmembrane serine protease) (Esophageal cancer-susceptibility gene 1 protein), TMPRSS11A, ECRG1 HATL1 HESP
Raised in
Species Reactivity
Homo sapiens
Recombinant Homo sapiens TMPRSS11A protein
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
Gene References into Functions
  1. ECRG1 Arg290Gln polymorphism significantly affects the susceptibility but not the prognosis of esophageal squamous cell carcinoma patients in low-risk north Indian population. PMID: 23869757
  2. This suggests that substitution of the arginine in the conserved catalytic domain of the ECRG1 protein might reduce its catalytic capacity by impacting its 3-dimensional conformation, thereby causing the genetic susceptibility to ESCC. [review] PMID: 23548972
  3. Data show that the allele types of ECRG1 were Arg/Arg (54.2%), Arg/Gln (45.8%) and Gln/Gln (0.00%), and the allele types of FGFR4 amino acid 388 were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%). PMID: 23481570
  4. A statistically significantly increased risk of ESCC was found to be associated with the ECRG1 Arg/Gln and Gln/Gln genotype. PMID: 21517269
  5. Data show that ECRG4 interacts directly with ECRG1 to upregulate p21 protein expression, induce cell cycle G1 phase block and inhibit cancer cells proliferation in ESCC. PMID: 21288367
  6. findings indicate that ECRG1 may be a candidate tumor suppressor gene for esophageal cancer involved in cell-cycle control PMID: 17971341
  7. DNA polymorphisms in the coding region of ECRG1 are associated with poor outcome after surgical resection in esophageal carcinoma. PMID: 19052822
  8. no significant association between single nucleotide polymorphisms Arg/Arg, Arg/Gln and Gln/Gln and survival in oral squamous cell carcinoma PMID: 19394797
  9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19826048
  10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19394797
  11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19052822

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Subcellular Location
Membrane; Single-pass type II membrane protein.
Protein Families
Peptidase S1 family
Tissue Specificity
Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.
Database Links

HGNC: 27954

OMIM: 611704

KEGG: hsa:339967

STRING: 9606.ENSP00000334611

UniGene: Hs.450110

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