TOM70 Antibody

Code CSB-PA024055XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TOM70 Polyclonal antibody
Uniprot No.
Target Names
TOM70
Alternative Names
TOM70; MAS70; OMP1; YNL121C; N1905; Mitochondrial import receptor subunit TOM70; 70 kDa mitochondrial outer membrane protein; Translocase of outer membrane 70 kDa subunit
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TOM70 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.
Gene References into Functions
  1. The Mim1 complex cooperates with the receptor Tom70 in binding of precursor proteins and promotes their insertion and assembly into the outer membrane. PMID: 21825073
  2. The import receptor Tom70, but not its partner Tom20, is in-volved in the initial recognition of the Ugo1 precursor. PMID: 21825074
  3. the malleability of the monomeric Tom70 receptor is an important factor in mitochondrial import PMID: 15316022
  4. The cytosolic fragment of yeast Tom70p (cTom70p) was crystallized. There are two Tom70p molecules in one asymmetric unit, which corresponds to a solvent content of approximately 51%. PMID: 16511318
  5. The crystal structure of Tom70p provides insights into the mechanisms of precursor transport across the mitochondrion's outer membrane. PMID: 16767096
  6. Data Show that Tom70 are anchored in the outer membrane by a single transmembrane alpha-helix, located at the N terminus of Tom70 (signal-anchored) and that Mim1 is required for efficient membrane insertion and assembly of Tom70. PMID: 17974559
  7. These data indicate an unexpected role for Tom70 in recruitment of soluble proteins to the mitochondrial surface, and indicate that Tom71 has a specialized role in Mfb1-mediated mitochondrial morphogenesis. PMID: 18007655
  8. Results suggest that the Tom70 monomer is the functional unit mediating initial chaperone docking and precursor recognition. PMID: 19358854

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Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein.
Protein Families
Tom70 family
Database Links

KEGG: sce:YNL121C

STRING: 4932.YNL121C

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