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Recombinant Saccharomyces cerevisiae Mitochondrial import receptor subunit TOM70 (TOM70), partial

Recombinant Saccharomyces cerevisiae Mitochondrial import receptor subunit TOM70 (TOM70), partial

Code	CSB-YP024055SVG1
Size	Pls inquire
Source	Yeast
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Code	CSB-EP024055SVG1
Size	Pls inquire
Source	E.coli
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Code	CSB-EP024055SVG1-B
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP024055SVG1
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP024055SVG1
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

TOM70

Uniprot No.

P07213

Alternative Names

TOM70; MAS70; OMP1; YNL121C; N1905; Mitochondrial import receptor subunit TOM70; 70 kDa mitochondrial outer membrane protein; Translocase of outer membrane 70 kDa subunit

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.

Gene References into Functions

The Mim1 complex cooperates with the receptor Tom70 in binding of precursor proteins and promotes their insertion and assembly into the outer membrane. PMID: 21825073
The import receptor Tom70, but not its partner Tom20, is in-volved in the initial recognition of the Ugo1 precursor. PMID: 21825074
the malleability of the monomeric Tom70 receptor is an important factor in mitochondrial import PMID: 15316022
The cytosolic fragment of yeast Tom70p (cTom70p) was crystallized. There are two Tom70p molecules in one asymmetric unit, which corresponds to a solvent content of approximately 51%. PMID: 16511318
The crystal structure of Tom70p provides insights into the mechanisms of precursor transport across the mitochondrion's outer membrane. PMID: 16767096
Data Show that Tom70 are anchored in the outer membrane by a single transmembrane alpha-helix, located at the N terminus of Tom70 (signal-anchored) and that Mim1 is required for efficient membrane insertion and assembly of Tom70. PMID: 17974559
These data indicate an unexpected role for Tom70 in recruitment of soluble proteins to the mitochondrial surface, and indicate that Tom71 has a specialized role in Mfb1-mediated mitochondrial morphogenesis. PMID: 18007655
Results suggest that the Tom70 monomer is the functional unit mediating initial chaperone docking and precursor recognition. PMID: 19358854