UL111A Antibody

Code CSB-PA517245ZA01HWW
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Product Details

Full Product Name Rabbit anti-Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) UL111A Polyclonal antibody
Uniprot No. F5HC71
Target Names UL111A
Alternative Names UL111A antibody; Viral interleukin-10 homolog antibody; cmvIL-10 antibody; vIL-10 antibody
Raised in Rabbit
Species Reactivity Human cytomegalovirus
Immunogen Recombinant Human cytomegalovirus UL111A protein
Immunogen Species Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Functional viral IL-10 homolog. Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites. Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and biological activities. IL-10 signaling pathway has several immunosuppressive activities that are exploited by the virus. Inhibits TLR-induced type I interferon production in host plasmacytoid dendritic cells.
Gene References into Functions
  1. Authors show that the previously observed downregulation of hsa-miR-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A. PMID: 25253336
  2. These results suggest a significant and wide-ranging role for cmvIL-10 in the progression of breast cancer. PMID: 24520416
  3. cIL-10 expressing CD4 T-cells are directed against latently expressed US28 and UL111A. PMID: 24130479
  4. This study identifies a novel role for viral IL-10 in driving M2c polarization, which may limit virus clearance by restricting proinflammatory and CD4(+) T cell responses at sites of infection. PMID: 23864618
  5. CmvIL-10 bound avidly to the same receptors on blood mononuclear cells and was as bio-potent as native human IL-10. PMID: 21402594

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Subcellular Location Secreted.
Protein Families IL-10 family
Database Links

KEGG: vg:3077506

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