codA Antibody

Code CSB-PA340707ZA01ENV
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Product Details

Full Product Name Rabbit anti-Escherichia coli (strain K12) codA Polyclonal antibody
Uniprot No. P25524
Target Names codA
Alternative Names codA antibody; b0337 antibody; JW0328Cytosine deaminase antibody; CD antibody; CDA antibody; CDase antibody; EC 3.5.4.1 antibody; Cytosine aminohydrolase antibody; Isoguanine deaminase antibody; EC 3.5.4.- antibody
Raised in Rabbit
Species Reactivity Escherichia coli
Immunogen Recombinant Escherichia coli codA protein
Immunogen Species Escherichia coli (strain K12)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5-fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non-cytotoxic precursor.
Gene References into Functions
  1. Data show that peptide deformylase, threonine dehydrogenase, and cytosine deaminase are very sensitve to hydrogen peroxide. PMID: 22411989
  2. Future therapeutic local application of cell-permeable cytosine deaminase-TLM fusion proteins together with a systemic fluorouracil prodrug application could result in profound hepatoma antitumor activities without apparent side effects. PMID: 15922474
Protein Families Metallo-dependent hydrolases superfamily, Cytosine deaminase family
Database Links

KEGG: ecj:JW0328

STRING: 316407.85674479

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