codA Antibody

Code CSB-PA340707ZA01ENV
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Product Details

Full Product Name
Rabbit anti-Escherichia coli (strain K12) codA Polyclonal antibody
Uniprot No.
Target Names
codA
Alternative Names
codA antibody; b0337 antibody; JW0328Cytosine deaminase antibody; CD antibody; CDA antibody; CDase antibody; EC 3.5.4.1 antibody; Cytosine aminohydrolase antibody; Isoguanine deaminase antibody; EC 3.5.4.- antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli
Immunogen
Recombinant Escherichia coli codA protein
Immunogen Species
Escherichia coli (strain K12)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5-fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non-cytotoxic precursor.
Gene References into Functions
  1. Data show that peptide deformylase, threonine dehydrogenase, and cytosine deaminase are very sensitve to hydrogen peroxide. PMID: 22411989
  2. Future therapeutic local application of cell-permeable cytosine deaminase-TLM fusion proteins together with a systemic fluorouracil prodrug application could result in profound hepatoma antitumor activities without apparent side effects. PMID: 15922474
Protein Families
Metallo-dependent hydrolases superfamily, Cytosine deaminase family
Database Links

KEGG: ecj:JW0328

STRING: 316407.85674479

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