Human Collectrin(TMEM27) ELISA kit

Code CSB-EL023823HU
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
transmembrane protein 27
Alternative Names
UNQ679 ELISA Kit; Collectrin ELISA Kit; kidney-specific membrane protein ELISA Kit; NX-17 ELISA Kit; NX17 ELISA Kit; PRO1312 ELISA Kit; Tmem27 ELISA Kit; TMM27_HUMAN ELISA Kit; Transmembrane protein 27 ELISA Kit; UNQ679/PRO1312 ELISA Kit
Abbreviation
TMEM27
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma,tissue homogenates, cell lysates
Detection Range
56 pg/mL-800 pg/mL
Sensitivity
24 pg/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Metabolism
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human TMEM27 ELISA Kit was designed for the quantitative measurement of Human TMEM27 protein in serum, plasma,tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 56 pg/mL-800 pg/mL and the sensitivity is 24 pg/mL.

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Target Background

Function
(From Uniprot)
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
Gene References into Functions
  1. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. PMID: 28764560
  2. Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. PMID: 27417314
  3. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. PMID: 24693993
  4. Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. PMID: 21907142
  5. Tmem27 dimerization is a dynamic process involving Bace2 PMID: 22628310
  6. Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
  7. Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. PMID: 20386877
  8. Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
  9. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. PMID: 19417552
  10. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease PMID: 19582483

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
TMEM27 family
Tissue Specificity
Kidney; collecting ducts. Pancreas; beta cells of islets.
Database Links

HGNC: 29437

OMIM: 300631

KEGG: hsa:57393

STRING: 9606.ENSP00000369699

UniGene: Hs.129614

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