Human Collectrin(TMEM27) ELISA kit

1. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. PMID: 28764560
2. Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. PMID: 27417314
3. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. PMID: 24693993
4. Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. PMID: 21907142
5. Tmem27 dimerization is a dynamic process involving Bace2 PMID: 22628310
6. Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
7. Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. PMID: 20386877
8. Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
9. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. PMID: 19417552
10. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease PMID: 19582483

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HGNC: 29437

OMIM: 300631

KEGG: hsa:57393

STRING: 9606.ENSP00000369699

UniGene: Hs.129614