Human Collectrin(TMEM27) ELISA kit

Code CSB-EL023823HU
Size 96T,5×96T,10×96T How to order?
Trial Size 24T ELISA kits trial application
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Product Details


This Human TMEM27 ELISA Kit was designed for the quantitative measurement of Human TMEM27 protein in serum, plasma,tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 56 pg/mL-800 pg/mL and the sensitivity is 24 pg/mL.

Target Name transmembrane protein 27
Alternative Names UNQ679 ELISA Kit; Collectrin ELISA Kit; kidney-specific membrane protein ELISA Kit; NX-17 ELISA Kit; NX17 ELISA Kit; PRO1312 ELISA Kit; Tmem27 ELISA Kit; TMM27_HUMAN ELISA Kit; Transmembrane protein 27 ELISA Kit; UNQ679/PRO1312 ELISA Kit
Abbreviation TMEM27
Uniprot No. Q9HBJ8
Species Homo sapiens (Human)
Sample Types serum, plasma,tissue homogenates, cell lysates
Detection Range 56 pg/mL-800 pg/mL
Sensitivity 24 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Metabolism
Assay Principle quantitative
Measurement Sandwich
ELISA Data Analysis Watch ELISA data processing video & download Curve Expert if needed
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

(From Uniprot)
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
Gene References into Functions
  1. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. PMID: 28764560
  2. Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. PMID: 27417314
  3. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. PMID: 24693993
  4. Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. PMID: 21907142
  5. Tmem27 dimerization is a dynamic process involving Bace2 PMID: 22628310
  6. Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
  7. Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. PMID: 20386877
  8. Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
  9. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. PMID: 19417552
  10. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease PMID: 19582483

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Subcellular Location Cell membrane; Single-pass type I membrane protein.
Protein Families TMEM27 family
Tissue Specificity Kidney; collecting ducts. Pancreas; beta cells of islets.
Database Links

HGNC: 29437

OMIM: 300631

KEGG: hsa:57393

STRING: 9606.ENSP00000369699

UniGene: Hs.129614

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