TMEM27 Antibody, FITC conjugated

Code CSB-PA881018EC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TMEM27 Polyclonal antibody
Uniprot No. Q9HBJ8
Target Names TMEM27
Alternative Names UNQ679 antibody; Collectrin antibody; kidney-specific membrane protein antibody; NX-17 antibody; NX17 antibody; PRO1312 antibody; Tmem27 antibody; TMM27_HUMAN antibody; Transmembrane protein 27 antibody; UNQ679/PRO1312 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Collectrin protein (15-141AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Regulator of SNARE complex function. Stimulator of beta cell replication.
Gene References into Functions
  1. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. PMID: 28764560
  2. Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. PMID: 27417314
  3. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. PMID: 24693993
  4. Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. PMID: 21907142
  5. Tmem27 dimerization is a dynamic process involving Bace2 PMID: 22628310
  6. Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
  7. Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. PMID: 20386877
  8. Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
  9. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. PMID: 19417552
  10. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease PMID: 19582483

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families TMEM27 family
Tissue Specificity Kidney; collecting ducts. Pancreas; beta cells of islets.
Database Links

HGNC: 29437

OMIM: 300631

KEGG: hsa:57393

STRING: 9606.ENSP00000369699

UniGene: Hs.129614

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