TMEM27 Antibody

Datasheet

Code	CSB-PA881018EA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA881018EA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA881018EA01HU at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using CSB-PA881018EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TMEM27 Polyclonal antibody

Uniprot No.

Q9HBJ8

Target Names

TMEM27

Alternative Names

UNQ679 antibody; Collectrin antibody; kidney-specific membrane protein antibody; NX-17 antibody; NX17 antibody; PRO1312 antibody; Tmem27 antibody; TMM27_HUMAN antibody; Transmembrane protein 27 antibody; UNQ679/PRO1312 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Collectrin protein (15-141AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TMEM27 Antibody (Product code: CSB-PA881018EA01HU) is Non-conjugated. For TMEM27 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA881018EB01HU	TMEM27 Antibody, HRP conjugated	ELISA
FITC	CSB-PA881018EC01HU	TMEM27 Antibody, FITC conjugated
Biotin	CSB-PA881018ED01HU	TMEM27 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.

Gene References into Functions

Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. PMID: 28764560
Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. PMID: 27417314
Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. PMID: 24693993
Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. PMID: 21907142
Tmem27 dimerization is a dynamic process involving Bace2 PMID: 22628310
Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. PMID: 20386877
Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. PMID: 19417552
No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease PMID: 19582483

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

TMEM27 family

Tissue Specificity

Kidney; collecting ducts. Pancreas; beta cells of islets.

Database Links

HGNC: 29437

OMIM: 300631

KEGG: hsa:57393

STRING: 9606.ENSP00000369699

UniGene: Hs.129614

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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