Recombinant Human Collectrin(TMEM27),partial

Code CSB-YP881018HU
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Source Yeast
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Code CSB-EP881018HU
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Source E.coli
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Code CSB-EP881018HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP881018HU
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Source Baculovirus
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Code CSB-MP881018HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names TMEM27
Uniprot No. Q9HBJ8
Alternative Names UNQ679; Collectrin; kidney-specific membrane protein; NX-17; NX17; PRO1312; Tmem27; TMM27_HUMAN; Transmembrane protein 27; UNQ679/PRO1312
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Regulator of SNARE complex function. Stimulator of beta cell replication.
Gene References into Functions
  1. Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. PMID: 28764560
  2. Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. PMID: 27417314
  3. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. PMID: 24693993
  4. Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. PMID: 21907142
  5. Tmem27 dimerization is a dynamic process involving Bace2 PMID: 22628310
  6. Collectrin and ACE2 in renal and intestinal amino acid transport. PMID: 21814048
  7. Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. PMID: 20386877
  8. Collectrin has a role in amino acid transpor in the kidney [review] PMID: 17693757
  9. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. PMID: 19417552
  10. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease PMID: 19582483

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families TMEM27 family
Tissue Specificity Kidney; collecting ducts. Pancreas; beta cells of islets.
Database Links

HGNC: 29437

OMIM: 300631

KEGG: hsa:57393

STRING: 9606.ENSP00000369699

UniGene: Hs.129614

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