Human Angiopoietin 2,ANG-2 ELISA Kit

Code CSB-E04500h
See More Details 24T ELISA kits trial application
Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. O15123
Lead Time 3-5 working days
Abbreviation ANGPT2
Protein Biological Process 1 Angiogenesis
Target Name angiopoietin 2
Alias AGPT2, ANG2, Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a
Species Homo sapiens (Human)
Protein Biological Process 3 Angiogenesis
Sample Types serum, plasma, tissue homogenates
Detection Range 39 pg/mL-2500 pg/mL
Sensitivity 9.75 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cardiovascular
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Assay Principle quantitative
Measurement Sandwich
Target Details This protein is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
HGNC 485
RGD 621861
MGI 1202890
Precision
Linearity
Recovery
Typical Data
References
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Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Subcellular Location Secreted
Database Links

HGNC: 485

OMIM: 601922

KEGG: hsa:285

STRING: 9606.ENSP00000314897

UniGene: Hs.583870

Pathway HIF-1 signaling pathway
MAPK signaling pathway
PI3K-Akt signaling pathway
Ras signaling pathway
Rap1 signaling pathway

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