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24T ELISA Kit Trial Size (Only USD$150/ kit)
The human ANGPT2 ELISA Kit is engineered for accurate measurement of human ANGPT2 levels from samples including serum, plasma, or tissue homogenates. It uses the Sandwich-ELISA mechanism in combination with the enzyme-substrate chromogenic reaction to measure the ANGPT2 content in the sample. The color intensity is positively correlated with the ANGPT2 content in the sample. This kit has been validated against standards of sensitivity and specificity.
ANGPT2, also termed Ang-2, one of the ligands for Tie2, enhances inflammation and permeability by inhibiting the action of Ang-1. It is involved in the induction of growth, cell migration, and mitosis of vascular smooth muscle cells, as well as elevated production of collagen type I and III in fibroblasts, resulting in thickening of the vascular wall and myocardium, and fibrosis. Additionally, Ang-2 also raises blood pressure (BP) primarily through vasoconstriction, sympathetic nervous stimulation, enhanced aldosterone biosynthesis, and renal actions. Ang-2 also participates in the process of atherosclerosis and in the remodeling and repair processes of the myocardium after myocardial infarction. Inhibiting Ang-2 signaling protects against neurodegenerative processes and promotes longevity in rodents.
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