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In the lymphatic endothelium, ANGPT2 works as an agonist, but in the blood endothelium, it acts as a competitive antagonist. ANGPT2 destabilizes vessel assembly, increases vessel permeability, and causes vascular plasticity via interrupting ANGPT1-TIE2 signaling. ANGPT2 has been discovered to be a powerful proangiogenic factor that works in tandem with VEGFA. ANGPT2 expression on ECs is induced by hypoxia and inflammation, which compromises endothelial integrity. TIE2 inhibition by ANGPT2 in blood arteries has been associated with the vascular leak, inflammation, and metastasis in illness.The recombinant ANGPT2 antibody is a monoclonal antibody generated by cloning ANGPT2 antibody genes into plasma vectors and transfecting vector clones into stable cell lines for production. For recombinant antibody generation, mammalian cell lines like CHO cells and HEK293 are commonly used. The recombinant ANGPT2 antibody was purified using Affinity-chromatography. It has verified to detect ANGPT2 protein from Human in the ELISA, IHC.
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