Angiopoietin-2 is a protein in humans that is encoded by ANGPT2 gene with a molecular mass of about 75kDa. This protein is about 60% identical to ANGPT1. The homology of ANGPT1 between humans and mice is as high as 97.6%. ANGPT1 is mainly expressed in myocardium, and later expressed in perivascular cells including peritubular cells, vascular smooth muscle cells and tumor cells. ANGPT2 is mainly secreted by endothelial cells. It is a natural competitive antagonist of ANGPT1.
ANGPT2 can competitively inhibit the phosphorylation of ANGPT1 to promote TIE2. It is mainly expressed in vascular endothelial cells and maintain the dynamic equilibrium of vascular growth and degeneration by inhibiting the activation of ANGPT1. In addition, the expression of ANGPT2 can be regulated by a variety of factors such as VEGF, EGF, bFGF, TNFα, etc. Hypoxia can promote the expression of ANGPT2, while ANGPT1 and TGF-β can down-regulate its expression level. The effect of ANGPT2 on angiogenesis is related to the local microenvironment. In the presence of VEGF, ANGPT2 can antagonize the effect of ANGPT1 on promoting vascular structure stability, which is beneficial to vascular sprouting and growth; when VEGF is lacking, ANGPT2 inhibits ANGPT1, which is beneficial to vascular regression.
Recombinant Human Angiopoietin-2(ANGPT2) (Active) (CSB-MP001707HU(A4))
Validated Data
Greater than 92% as determined by SDS-PAGE.
Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody (CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL.
The following ANGPT2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ANGPT2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA05749A0Rb | ANGPT2 Antibody |
Human, Mouse, Rat | ELISA, WB, IHC |
CSB-PA05749D0Rb | ANGPT2 Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA05749B0Rb | ANGPT2 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA083784 | ANGPT2 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA694467 | ANGPT2 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-RA191985A0HU | ANGPT2 Antibody |
Human | ELISA, IHC |
CSB-RA001707MA01HU | ANGPT2 Monoclonal Antibody |
Human | ELISA |
ANGPT2 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA16959D0Rb | Angpt2 Antibody, Biotin conjugated |
Mouse | ELISA |
CSB-PA16959B0Rb | Angpt2 Antibody, HRP conjugated |
Mouse | ELISA |
CSB-PA16959A0Rb | Angpt2 Antibody |
Mouse | ELISA, WB, IHC |
ANGPT2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP001707DO CSB-BP001707DO CSB-MP001707DO CSB-EP001707DO-B |
Recombinant Dog Angiopoietin-2(ANGPT2) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP001707MO CSB-EP001707MO CSB-BP001707MO CSB-MP001707MO CSB-EP001707MO-B |
Recombinant Mouse Angiopoietin-2(Angpt2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP169594m | Recombinant Mouse Angiopoietin-2(Angpt2),partial |
E.coli |
ANGPT2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP001707RA CSB-EP001707RA CSB-MP001707RA CSB-EP001707RA-B |
Recombinant Rat Angiopoietin-2(Angpt2) |
Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP001707BO CSB-EP001707BO CSB-BP001707BO CSB-MP001707BO CSB-EP001707BO-B |
Recombinant Bovine Angiopoietin-2(ANGPT2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP859369PI CSB-EP859369PI CSB-BP859369PI CSB-MP859369PI CSB-EP859369PI-B |
Recombinant Pig Angiopoietin-2(ANGPT2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP001707HU | Recombinant Human Angiopoietin-2(ANGPT2),partial |
E.coli |
CSB-BP001707HU CSB-MP001707HU CSB-EP001707HU-B |
Recombinant Human Angiopoietin-2(ANGPT2),partial |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-YP001707HU | Recombinant Human Angiopoietin-2(ANGPT2),partial |
Yeast |
CSB-MP001707HU(A4) | Recombinant Human Angiopoietin-2(ANGPT2) (Active) |
Mammalian cell |
ANGPT2 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04500h | Human Angiopoietin 2,ANG-2 ELISA Kit |
serum, plasma, tissue homogenates | 9.75 pg/mL |
ANGPT2 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07305m | Mouse Angiopoietin 2,ANG-2 ELISA Kit |
serum, plasma, cell culture supernates, tissue homogenates | 0.039 pg/mL |
ANGPT2 ELISA Kit for Sus scrofa (Pig)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E08460p | Pig Angiopoietin 2,ANG-2 ELISA Kit |
serum, plasma, tissue homogenates | 0.235 ng/mL |
ANGPT2 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07304r | Rat Angiopoietin 2,ANG-2 ELISA Kit |