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ANGPT2 (Angiopoietin-2) is a protein associated with angiogenesis and vascular stability, belonging to the angiogenic regulatory factor family. It cooperates with another related protein, ANGPT1 (Angiopoietin-1), in regulating the function of the vascular system. ANGPT2 primarily exists in a monomeric form in solution. It acts as an inhibitor, preventing the formation of new blood vessels. It interacts with ANGPT1 to regulate the adhesion, migration, and growth of endothelial cells, affecting the stability and maturity of blood vessels. ANGPT2 can also increase vascular permeability, making the blood vessel walls unstable and causing plasma components to leak into surrounding tissues. Aberrant expression of ANGPT2 is associated with certain diseases, including cancer, diabetes, and inflammatory conditions. Due to its critical role in angiogenesis and vascular permeability regulation, ANGPT2 has become a target for drug development in the treatment of vascular-related diseases.
● Recombinant Human Angiopoietin-2(ANGPT2) (Active) CSB-MP001707HU(A4)
Validated Data
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CSB-MP882153HU is detected by Mouse anti-6*His monoclonal antibody.
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Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL.
● ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU
Validated Data
The Binding Activity of ANGPT2 with anti-ANGPT2 antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2(CSB-MP001707HU(A4)) at 2 μg/mL can bind Anti-ANGPT2 recombinant antibody, the EC50 is 0.6666-0.8876 ng/mL.
● ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU
Validated Data
IHC image of CSB-RA191985A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA191985A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
The following ANGPT2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ANGPT2 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA05749A0Rb | ANGPT2 Antibody |
Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA05749D0Rb | ANGPT2 Antibody, Biotin conjugated |
Human | ELISA |
| CSB-PA05749B0Rb | ANGPT2 Antibody, HRP conjugated |
Human | ELISA |
| CSB-PA083784 | ANGPT2 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA694467 | ANGPT2 Antibody |
Human,Mouse,Rat | ELISA,IHC |
| CSB-RA191985A0HU | ANGPT2 Recombinant Monoclonal Antibody |
Human | ELISA, IHC |
| CSB-RA001707MA01HU | ANGPT2 Recombinant Monoclonal Antibody |
Human | ELISA |
ANGPT2 Antibodies for Mus musculus (Mouse)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA16959D0Rb | Angpt2 Antibody, Biotin conjugated |
Mouse | ELISA |
| CSB-PA16959B0Rb | Angpt2 Antibody, HRP conjugated |
Mouse | ELISA |
| CSB-PA16959A0Rb | Angpt2 Antibody |
Mouse | ELISA, WB, IHC |
ANGPT2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP001707DO CSB-BP001707DO CSB-MP001707DO CSB-EP001707DO-B |
Recombinant Dog Angiopoietin-2 (ANGPT2) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP001707MO CSB-EP001707MO CSB-BP001707MO CSB-MP001707MO CSB-EP001707MO-B |
Recombinant Mouse Angiopoietin-2 (Angpt2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP169594m | Recombinant Mouse Angiopoietin-2 (Angpt2), partial |
E.coli |
ANGPT2 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP001707RA CSB-EP001707RA CSB-MP001707RA CSB-EP001707RA-B |
Recombinant Rat Angiopoietin-2 (Angpt2) |
Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP001707RA | Recombinant Rat Angiopoietin-2 (Angpt2) |
Baculovirus |
| CSB-EP001707RAa0 | Recombinant Rat Angiopoietin-2 (Angpt2) |
E.coli |
| CSB-BP001706RAc7 | Recombinant Rat Angiopoietin-1 (Angpt1) |
Baculovirus |
ANGPT2 Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP001707BO CSB-EP001707BO CSB-BP001707BO CSB-MP001707BO CSB-EP001707BO-B |
Recombinant Bovine Angiopoietin-2 (ANGPT2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Sus scrofa (Pig)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP859369PI CSB-BP859369PI CSB-MP859369PI CSB-EP859369PI-B |
Recombinant Pig Angiopoietin-2 (ANGPT2) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP001707HU | Recombinant Human Angiopoietin-2 (ANGPT2), partial |
E.coli |
| CSB-BP001707HU CSB-MP001707HU CSB-EP001707HU-B |
Recombinant Human Angiopoietin-2 (ANGPT2), partial |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP001707HU | Recombinant Human Angiopoietin-2 (ANGPT2), partial |
Yeast |
| CSB-MP001707HU(A4) | Recombinant Human Angiopoietin-2 (ANGPT2) (Active) |
Mammalian cell |
ANGPT2 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04500h | Human Angiopoietin 2,ANG-2 ELISA Kit |
serum, plasma, tissue homogenates | 9.75 pg/mL |
ANGPT2 ELISA Kit for Mus musculus (Mouse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E07305m | Mouse Angiopoietin 2,ANG-2 ELISA Kit |
serum, plasma, cell culture supernates, tissue homogenates | 0.039 pg/mL |
ANGPT2 ELISA Kit for Sus scrofa (Pig)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08460p | Pig Angiopoietin 2,ANG-2 ELISA Kit |
serum, plasma, tissue homogenates | 0.235 ng/mL |
ANGPT2 ELISA Kit for Rattus norvegicus (Rat)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E07304r | Rat Angiopoietin 2,ANG-2 ELISA Kit |
serum, plasma, tissue homogenates. | 0.02 ng/ml |
