Human E3 ubiquitin-protein ligase TRIM63(TRIM63) ELISA kit

1. role of the muscle specific E3s MuRF-1 and MAFbx in skeletal muscle wasting during various pathologies, as well as their regulation by modifiable lifestyle factors, were explored (review) PMID: 26738803
2. the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system PMID: 27526027
3. The mitochondrial damage-cGAS-STING-IRF3 pathway is critically involved in metabolic stress-induced endothelial inflammation. PMID: 28302626
4. Altogether, these results suggest a novel function for p63 as a contributor to muscular atrophic processes via the regulation of multiple genes, including the muscle atrophy gene Trim63. PMID: 26919175
5. Vitamin D3 might have an inhibitory effect on the expression of MAFbx and MuRF1 in skeletal muscle. PMID: 25876656
6. MURF1 expression intended to be increased in the skeletal muscle of patients with malignant disease even before cancer related cachexia weight loss. PMID: 25760630
7. TRIM63 gene expression involved in skin hyperpigmentation. PMID: 25950827
8. Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles PMID: 26048142
9. Skeletal muscle atrophy induced by Angiotensin II involves activation of MuRF1 expression. PMID: 26137861
10. These data strongly supported that rare variants in MuRF1 and MuRF2 are associated with higher penetrance and more severe clinical manifestations of hypertrophic cardiomyopathy. PMID: 24865491
11. In conclusion, atrogin-1, MuRF1, FOXO1/3A, and eIF3-f mRNA, and protein levels, are differentially regulated by exercise contraction mode but not WPH supplementation combined with hypertrophy-inducing training. PMID: 24458747
12. Data reveal that Titin protein is a pseudokinase with non-detectable catalytic output but is a high-affinity binding locus for MuRF1. PMID: 24850911
13. both MuRF1 and MAFbx are enriched in skeletal, cardiac, and smooth muscle--REVIEW PMID: 25096180
14. SMAD3 regulates transcription of MuRF-1 by increasing FoxO3 binding at a conserved FRE-SBE motif within the proximal promoter region, and by increasing FoxO3 protein content and transcriptional activity. PMID: 24920680
15. In MuRF1 the COS-box mediates the in vivo targeting of sarcoskeletal structures and points to the pharmacological relevance of the COS domain for treating MuRF1-mediated muscle atrophy. PMID: 24671946
16. MURF-1 protein gene expression is increased in patients with severe burn injury. PMID: 23816995
17. Quadriceps muscle MuRF-1 levels did not differ between patients with COPD (with normal or low fat-free mass index) and controls. MURF1 levels were not associated with quadriceps fiber cross-sectional area or strength in patients. PMID: 23844868
18. Regular exercise training leads to a decrease in Rnf28 expression in skeletal muscle in patients with advanced chronic heart failure. PMID: 22445192
19. relationship was found between IL-6 and MuRF-1 expression after incubation with PGE2 PMID: 23490068
20. MuRF-1 RNA expression was significantly increased in malnourished cirrhotic patients vs. well-nourished patients. PMID: 23432902
21. Data suggest that expression of atrogin-1 and MuRF-1 likely play role in aging-related decrease in muscle mass (i.e., development of sarcopenia); up-regulation of atrogin-1 and MuRF-1 has potential to prevent or reverse sarcopenia. [REVIEW] PMID: 22815045
22. Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy. PMID: 22821932
23. investigation of factors regulating expression of two ubiquitin ligases (MURF1 and MAFbx) in skeletal muscle (i.e., vastus lateralis): effects of resistance exercise and anabolic dietary supplement (i.e., branched-chain amino acids) PMID: 22127230
24. Data suggest that the inhibition of MuRF1 could be a novel mechanism to prevent or reverse muscle wasting associated with various pathologies. PMID: 21448668
25. MuRF1 regulates cardiomyocyte cell size and energy metabolism to inhibit cardiac hypertrophy and reverse experimental cardiac hypertrophy. PMID: 21686210
26. 11beta-HSD1 controls glucocorticoid-induced protein degradation in human and murine skeletal muscle via regulation of the E3 ubiquitin ligases Atrogin-1 and MuRF-1. PMID: 21304964
27. Reduced expression of MuRF1 and MAFbx in the myocardium might permit hypertrophy characteristic of the early post-infarction remodeling phase. PMID: 19859778
28. atrogin-1 specifically targets truncated M7t-cMyBP-C, but not WT-cMyBP-C, for proteasomal degradation and that MuRF1 indirectly reduces cMyBP-C levels by regulating the transcription of myosin heavy chain. PMID: 19850579
29. interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. PMID: 11927605
30. MURF2 associates transiently with microtubules, myosin and titin during sarcomere assembly. PMID: 12414993
31. MuRF1 functions as a ubiquitin ligase to catalyze ubiquitylation of troponin I through a RING finger-dependent mechanism PMID: 15601779
32. MuRF1 mRNA expression was significantly increased in quadriceps of patients with COPD; transcriptional regulation of atrogin-1 and MuRF1 may occur via FoxO-1, but independently of AKT PMID: 17478621
33. Expression of mRNA for MuRF-1 increased approximately 3-fold at 10 days without changes in MAFbx or tripeptidyl peptidase II mRNA, but all decreased between 10 and 21 days of muscle disuse. PMID: 17901116
34. MuRF-1 and MAFbx, are differently affected by the exercise as well as by repeated exercise PMID: 17971512
35. Results showed upregulation of MuRf1 and MAFbx in atrophied muscle and support their role as regulatory peptides in various conditions which lead to muscle atrophy. PMID: 17977773
36. MuRF1 expression in skeletal muscle re-directs glycogen synthesis to the liver and stimulates pancreatic insulin secretion, providing a feedback loop that connects skeletal muscle metabolism with the liver and the pancreas during metabolic stress. PMID: 18468620
37. These findings present new insights into the role of the glucocorticoid receptor and FOXO family of transcription factors in the transcriptional regulation of the MuRF1 gene PMID: 18612045
38. Findings aid the future exploration of the cellular function and therapeutic potential of MuRF1. PMID: 18795805
39. This study demenostrated that the muscle RING finger 1 protein, human is reduced in skeletal muscle of chronic spinal cord-injured patients. PMID: 19533653

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HGNC: 16007

OMIM: 606131

KEGG: hsa:84676

STRING: 9606.ENSP00000363390

UniGene: Hs.279709