Human Interleukin-27 receptor subunit alpha(IL27RA) ELISA kit

Code CSB-EL011644HU
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
interleukin 27 receptor, alpha
Alternative Names
Class I cytokine receptor ELISA Kit; CRL1 ELISA Kit; Cytokine receptor-like 1 ELISA Kit; I27RA_HUMAN ELISA Kit; IL-27 receptor subunit alpha ELISA Kit; IL-27R subunit alpha ELISA Kit; IL-27R-alpha ELISA Kit; IL-27RA ELISA Kit; IL27R alpha ELISA Kit; IL27R ELISA Kit; Il27ra ELISA Kit; Interleukin 27 receptor alpha chain precursor ELISA Kit; Interleukin 27 receptor ELISA Kit; Interleukin-27 receptor subunit alpha ELISA Kit; Protein CRL1 ELISA Kit; T cell cytokine receptor type 1 ELISA Kit; TCCR ELISA Kit; Type 1 T cell cytokine receptor ELISA Kit; Type I T-cell cytokine receptor ELISA Kit; WSX-1 ELISA Kit; WSX1 ELISA Kit; ZcytoR1 ELISA Kit
Abbreviation
IL27RA
Uniprot No.
Species
Homo sapiens (Human)
Detection Range
Request Information
Sensitivity
Request Information
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Others
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

Customer Reviews and Q&A

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 Q&A
Q:

I would like to know the type of capture and secondary antibody included in the CSB-EL011644HU kit.

A:
Thanks for your inquiry!The capture is mouse monoclonal antibody and the detection antibody is goat polyclonal antibody
Q:

I want to know the antigen that each antibody catches.

A:
This kit is directed to extracellular domain(33-516).The standard is 293 cell-derived recombinant protein and immunogen is 293 cell-derived recombinant protein
Q:

I would like to inquire about the sample type of ELISA Kit.
The product number is #CSB-EL011644H.
Can analyze cell supernants using this ELISA Kit?
Also, which media should I use to melt the standard?

A:
Thanks for your inquiry!We usually use this kit to detect serum, plasma, tissuehomogenates, cell lysates samples.The datasheet is attached for your information.We suggest the customer detect cell lysates samples.And he/she had better to do pre-testing first.

The standard in this kit is Frozen powder and it needs to be centrifuged.The customer can use Sample Diluent to melt the standard.He/She can refer to the "Standard" part on page 8.

Target Background

Function
(From Uniprot)
Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Gene References into Functions
  1. this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth PMID: 28756371
  2. These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection. PMID: 28592538
  3. Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells PMID: 26649511
  4. The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID: 26282876
  5. natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27. PMID: 24771852
  6. Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes. PMID: 22936014
  7. TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration. PMID: 22312192
  8. Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. PMID: 21631431
  9. WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation. PMID: 12734330
  10. WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27. PMID: 14764690
  11. IL-27R possesses hematopoietic cell-transforming properties PMID: 18003935
  12. These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761
  13. Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID: 19549909

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity
Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, s
Database Links

HGNC: 17290

OMIM: 605350

KEGG: hsa:9466

STRING: 9606.ENSP00000263379

UniGene: Hs.132781

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