Name: Human Interleukin-27 receptor subunit alpha(IL27RA) ELISA kit
Brand: CUSABIO
SKU: CSB-EL011644HU

Product Details

Target Name

interleukin 27 receptor, alpha

Alternative Names

Class I cytokine receptor ELISA Kit; CRL1 ELISA Kit; Cytokine receptor-like 1 ELISA Kit; I27RA_HUMAN ELISA Kit; IL-27 receptor subunit alpha ELISA Kit; IL-27R subunit alpha ELISA Kit; IL-27R-alpha ELISA Kit; IL-27RA ELISA Kit; IL27R alpha ELISA Kit; IL27R ELISA Kit; Il27ra ELISA Kit; Interleukin 27 receptor alpha chain precursor ELISA Kit; Interleukin 27 receptor ELISA Kit; Interleukin-27 receptor subunit alpha ELISA Kit; Protein CRL1 ELISA Kit; T cell cytokine receptor type 1 ELISA Kit; TCCR ELISA Kit; Type 1 T cell cytokine receptor ELISA Kit; Type I T-cell cytokine receptor ELISA Kit; WSX-1 ELISA Kit; WSX1 ELISA Kit; ZcytoR1 ELISA Kit

Abbreviation

IL27RA

Uniprot No.

Q6UWB1

Species

Homo sapiens (Human)

Detection Range

Request Information

Sensitivity

Request Information

Assay Time

1-5h

Sample Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Others

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.

Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

I would like to know the type of capture and secondary antibody included in the CSB-EL011644HU kit.

Thanks for your inquiry!The capture is mouse monoclonal antibody and the detection antibody is goat polyclonal antibody

I want to know the antigen that each antibody catches.

This kit is directed to extracellular domain（33-516）.The standard is 293 cell-derived recombinant protein and immunogen is 293 cell-derived recombinant protein

I would like to inquire about the sample type of ELISA Kit.
The product number is #CSB-EL011644H.
Can analyze cell supernants using this ELISA Kit?
Also, which media should I use to melt the standard?

Thanks for your inquiry!We usually use this kit to detect serum, plasma, tissuehomogenates, cell lysates samples.The datasheet is attached for your information.We suggest the customer detect cell lysates samples.And he/she had better to do pre-testing first.

The standard in this kit is Frozen powder and it needs to be centrifuged.The customer can use Sample Diluent to melt the standard.He/She can refer to the "Standard" part on page 8.

Target Background

Function
(From Uniprot)

Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

Gene References into Functions

this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth PMID: 28756371
These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection. PMID: 28592538
Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells PMID: 26649511
The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID: 26282876
natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27. PMID: 24771852
Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes. PMID: 22936014
TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration. PMID: 22312192
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. PMID: 21631431
WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation. PMID: 12734330
WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27. PMID: 14764690
IL-27R possesses hematopoietic cell-transforming properties PMID: 18003935
These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761
Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID: 19549909

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Type I cytokine receptor family, Type 2 subfamily

Tissue Specificity

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, s

Database Links

HGNC: 17290

OMIM: 605350

KEGG: hsa:9466

STRING: 9606.ENSP00000263379

UniGene: Hs.132781

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Code	CSB-EL011644HU
Size	96T,5×96T,10×96T
Price	Request a Quote
Trial Size	24T ELISA Kit Trial Size (Only USD$150/ kit) * Sample kit cost can be deducted as a $30 credit for each 96-assay kit of the same analyte and brand you subsequently purchase within six months until depleted. More details >> Interested in a trial size? Please leave a message below.
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Human Interleukin-27 receptor subunit alpha(IL27RA) ELISA kit

Product Details

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Target Background