Recombinant Human Interleukin-27 receptor subunit alpha(IL27RA),partial

Code CSB-YP761488HU
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Source Yeast
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Code CSB-EP761488HU
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Source E.coli
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Code CSB-EP761488HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP761488HU
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Source Baculovirus
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Code CSB-MP761488HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names IL27RA
Uniprot No. Q6UWB1
Alternative Names Class I cytokine receptor; CRL1; Cytokine receptor-like 1; I27RA_HUMAN; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; IL27R alpha; IL27R; Il27ra; Interleukin 27 receptor alpha chain precursor; Interleukin 27 receptor; Interleukin-27 receptor subunit alpha; Protein CRL1; T cell cytokine receptor type 1; TCCR; Type 1 T cell cytokine receptor; Type I T-cell cytokine receptor; WSX-1; WSX1; ZcytoR1
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Gene References into Functions
  1. this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth PMID: 28756371
  2. These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection. PMID: 28592538
  3. Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells PMID: 26649511
  4. The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID: 26282876
  5. natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27. PMID: 24771852
  6. Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes. PMID: 22936014
  7. TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration. PMID: 22312192
  8. Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. PMID: 21631431
  9. WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation. PMID: 12734330
  10. WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27. PMID: 14764690
  11. IL-27R possesses hematopoietic cell-transforming properties PMID: 18003935
  12. These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761
  13. Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID: 19549909

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, s
Database Links

HGNC: 17290

OMIM: 605350

KEGG: hsa:9466

STRING: 9606.ENSP00000263379

UniGene: Hs.132781

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