Human Osteoclast-associated immunoglobulin-like receptor(OSCAR) ELISA kit

Code CSB-EL017255HU
Size 96T,5×96T,10×96T
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Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
osteoclast associated, immunoglobulin-like receptor
Alternative Names
OSCAR ELISA Kit; Osteoclast-associated immunoglobulin-like receptor ELISA Kit; Osteoclast-associated receptor ELISA Kit; hOSCAR ELISA Kit; Polymeric immunoglobulin receptor 3 ELISA Kit; PIgR-3 ELISA Kit; PIgR3 ELISA Kit; Poly-Ig receptor 3 ELISA Kit
Uniprot No.
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
6.25 ng/mL-400 ng/mL
1.56 ng/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Assay Principle
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
To assess the linearity of the assay, samples were spiked with high concentrations of human OSCAR in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
1:1Average %91
Range %86-95
1:2Average %96
Range %90-103
1:4Average %102
Range %98-106
1:8Average %88
Range %85-91
The recovery of human OSCAR spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample TypeAverage % RecoveryRange
Serum (n=5) 9187-95
EDTA plasma (n=4)9894-102
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
4002.604 2.788 2.696 2.535
2002.168 2.033 2.101 1.940
1001.423 1.521 1.472 1.311
500.878 0.860 0.869 0.708
250.636 0.623 0.630 0.469
12.50.414 0.454 0.434 0.273
6.250.233 0.246 0.240 0.079
00.156 0.166 0.161
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

This Human OSCAR ELISA Kit was designed for the quantitative measurement of Human OSCAR protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 6.25 ng/mL-400 ng/mL and the sensitivity is 1.56 ng/mL.

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Target Background

(From Uniprot)
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
Gene References into Functions
  1. regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts PMID: 28555364
  2. OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis. PMID: 26786702
  3. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1. PMID: 26552697
  4. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. PMID: 25716998
  5. Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients. PMID: 23146195
  6. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA. PMID: 24448348
  7. Rotative stress in mouse cells results in increased levels of Oscar transcription. PMID: 22949349
  8. endothelial cell-derived OSCAR was found to be involved in the STAT signaling pathway and to affect monocyte adhesion. PMID: 22985931
  9. OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1 PMID: 22009730
  10. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID: 21841309
  11. This review discusses the structure-function relationship, expression pattern, and physiological role of OSCAR in osteoimmunology and summarizes its potential implications for human diseases. PMID: 21172874
  12. hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response. PMID: 15155468
  13. ligation of OSCAR promotes dendritic cell survival by an ERK- and PI3K-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules PMID: 15650060
  14. Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j receptor. PMID: 15905516
  15. Promoter variant in OSCAR gene (OSCAR-2322A>G) might be one of genetic determinants of bone density in postmenopausal women. PMID: 16007331
  16. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts PMID: 16109714
  17. OSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses. PMID: 16493074
  18. OSCAR (osteoclast associated immunoglobulin-like receptor)is expressed by erosion front osteoclasts and by synovial microvessels mononuclear cells. OSCAR is induced in monocytes of rheumatod arthritis patients, facilitating osteoclast differentiation PMID: 18821671

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Subcellular Location
[Isoform 1]: Secreted.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
Protein Families
Leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
Database Links

HGNC: 29960

OMIM: 606862

KEGG: hsa:126014

STRING: 9606.ENSP00000352671

UniGene: Hs.347655

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