OSCAR Antibody

1. regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts PMID: 28555364
2. OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis. PMID: 26786702
3. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1. PMID: 26552697
4. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. PMID: 25716998
5. Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients. PMID: 23146195
6. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA. PMID: 24448348
7. Rotative stress in mouse cells results in increased levels of Oscar transcription. PMID: 22949349
8. endothelial cell-derived OSCAR was found to be involved in the STAT signaling pathway and to affect monocyte adhesion. PMID: 22985931
9. OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1 PMID: 22009730
10. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID: 21841309
11. This review discusses the structure-function relationship, expression pattern, and physiological role of OSCAR in osteoimmunology and summarizes its potential implications for human diseases. PMID: 21172874
12. hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response. PMID: 15155468
13. ligation of OSCAR promotes dendritic cell survival by an ERK- and PI3K-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules PMID: 15650060
14. Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j receptor. PMID: 15905516
15. Promoter variant in OSCAR gene (OSCAR-2322A>G) might be one of genetic determinants of bone density in postmenopausal women. PMID: 16007331
16. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts PMID: 16109714
17. OSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses. PMID: 16493074
18. OSCAR (osteoclast associated immunoglobulin-like receptor)is expressed by erosion front osteoclasts and by synovial microvessels mononuclear cells. OSCAR is induced in monocytes of rheumatod arthritis patients, facilitating osteoclast differentiation PMID: 18821671

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HGNC: 29960

OMIM: 606862

KEGG: hsa:126014

STRING: 9606.ENSP00000352671

UniGene: Hs.347655