Recombinant Human Osteoclast-associated immunoglobulin-like receptor (OSCAR)

Code CSB-YP811628HU
MSDS
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Source Yeast
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Code CSB-EP811628HU
MSDS
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Source E.coli
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Code CSB-EP811628HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP811628HU
MSDS
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Source Baculovirus
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Code CSB-MP811628HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
OSCAR
Uniprot No.
Alternative Names
OSCAR; Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; hOSCAR; Polymeric immunoglobulin receptor 3; PIgR-3; PIgR3; Poly-Ig receptor 3
Species
Homo sapiens (Human)
Expression Region
19-282
Target Protein Sequence
DI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT LRCRAPQPAW RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGIYRC CYRRPDWGPG VWSQPSDVLE LLVTEELPRP SLVALPGPVV GPGANVSLRC AGRLRNMSFV LYREGVAAPL QYRHSAQPWA DFTLLGARAP GTYSCYYHTP SAPYVLSQRS EVLVISWEGE GPEARPASSA PGMQAPGPPP SDPGAQAPSL SSFRPRGLVL QPLLPQTQDS WDPAPPPSDP GV
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
Gene References into Functions
  1. regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts PMID: 28555364
  2. OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis. PMID: 26786702
  3. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1. PMID: 26552697
  4. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. PMID: 25716998
  5. Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients. PMID: 23146195
  6. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA. PMID: 24448348
  7. Rotative stress in mouse cells results in increased levels of Oscar transcription. PMID: 22949349
  8. endothelial cell-derived OSCAR was found to be involved in the STAT signaling pathway and to affect monocyte adhesion. PMID: 22985931
  9. OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1 PMID: 22009730
  10. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID: 21841309
  11. This review discusses the structure-function relationship, expression pattern, and physiological role of OSCAR in osteoimmunology and summarizes its potential implications for human diseases. PMID: 21172874
  12. hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response. PMID: 15155468
  13. ligation of OSCAR promotes dendritic cell survival by an ERK- and PI3K-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules PMID: 15650060
  14. Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j receptor. PMID: 15905516
  15. Promoter variant in OSCAR gene (OSCAR-2322A>G) might be one of genetic determinants of bone density in postmenopausal women. PMID: 16007331
  16. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts PMID: 16109714
  17. OSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses. PMID: 16493074
  18. OSCAR (osteoclast associated immunoglobulin-like receptor)is expressed by erosion front osteoclasts and by synovial microvessels mononuclear cells. OSCAR is induced in monocytes of rheumatod arthritis patients, facilitating osteoclast differentiation PMID: 18821671

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Subcellular Location
[Isoform 1]: Secreted.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
Protein Families
Leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
Database Links

HGNC: 29960

OMIM: 606862

KEGG: hsa:126014

STRING: 9606.ENSP00000352671

UniGene: Hs.347655

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