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Human U3 small nucleolar ribonucleoprotein protein IMP3(IMP3) ELISA kit

Citations (1) Protocol
Code CSB-EL011692HU
Size 96T,5×96T,10×96T
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Product Details

Target Name
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
Alternative Names
BRMS2 ELISA Kit; C15orf12 ELISA Kit; Chromosome 15 open reading frame 12 ELISA Kit; DKFZp586L0118 ELISA Kit; FLJ10968 ELISA Kit; imp3 ELISA Kit; IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) ELISA Kit; IMP3_HUMAN ELISA Kit; Mitochondrial ribosomal protein S4 ELISA Kit; MRPS4 ELISA Kit; OTTHUMP00000183524 ELISA Kit; U3 small nucleolar ribonucleoprotein protein imp3 ELISA Kit; U3 snoRNP protein 3 homolog ELISA Kit; U3 snoRNP protein imp3 ELISA Kit
Abbreviation
IMP3
Uniprot No.
Q9NV31
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates, cell lysates
Detection Range
39 pg/mL-2500 pg/mL
Sensitivity
9.75 pg/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Metabolism
Assay Principle
quantitative
Measurement
Sandwich
Precision
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
Linearity
To assess the linearity of the assay, samples were spiked with high concentrations of human IMP3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
　 Sample Serum(n=4)
1:1 Average % 95
Range % 89-99
1:2 Average % 97
Range % 91-103
1:4 Average % 92
Range % 87-98
1:8 Average % 89
Range % 85-93
Recovery
The recovery of human IMP3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type Average % Recovery Range
Serum (n=5) 102 98-105
EDTA plasma (n=4) 86 80-91
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
pg/ml OD1 OD2 Average Corrected
2500 2.445 2.555 2.500 2.344
1250 1.791 1.861 1.826 1.670
625 1.232 1.287 1.260 1.104
312 0.866 0.877 0.872 0.716
156 0.580 0.593 0.587 0.431
78 0.437 0.424 0.431 0.275
39 0.283 0.289 0.286 0.130
0 0.155 0.156 0.156 　
ELISA Data Analysis
ELISA Standard Curve & Curve Expert software
Troubleshooting
and FAQs
ELISA kit FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human IMP3 ELISA Kit was designed for the quantitative measurement of Human IMP3 protein in serum, plasma, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 39 pg/mL-2500 pg/mL and the sensitivity is 9.75 pg/mL.

Citations

Related Products

IMP3 antibodies

IMP3 Proteins

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Target Background

Function
(From Uniprot)
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
Gene References into Functions
  1. our study found that IMP3 expression was higher in the ovarian clear cell carcinoma than the high grade serous and endometrioid subtypes PMID: 29866423
  2. IMP3 expression in uterine leiomyosarcoma could be a marker of a poor prognosis. PMID: 29077232
  3. IMP3 positive pT1 EAC revealed higher levels of lymph node metastases. PMID: 29974234
  4. IMP3 is a strong prognostic factor in non-neuroendocrine brain metastases and in particular in patients with adenocarcinoma metastases.IMP3 expression is associated with poor prognosis in patients with non-small cell lung cancer brain metastases. PMID: 29209838
  5. Study found IMP3 frequently overexpressed in many human neoplasms and show significant associations with adverse tumor features in esophageal adenocarcinomas and cancers of the urinary bladder, lung, stomach, and pancreas. PMID: 29115542
  6. In this study, IMP3 at the nodal site resulted to be associated with low progression-free survival in small-intestine neuroendocrine neoplasms, independently of the Ki-67 index. PMID: 28210937
  7. IMP3 may contribute to the aggressive behavior of metaplastic breast carcinoma , and that this expression could potentially be a prognostic marker PMID: 29146055
  8. These findings suggest that IMP3 expression has prognostic value as a biomarker for chemosensitivity and overall survival in triple negative breast cancer PMID: 28756977
  9. This study establishes p65 as a novel target of IMP3 in increasing glioma cell migration and underscores the significance of IMP3-p65 feedback loop for therapeutic targeting in GBM. PMID: 28465487
  10. IMP3 has a similar specificity, but a better sensitivity, intensity, and extent of reactivity in comparison with AMACR, and may be used as an alternative to AMACR, in support of the diagnosis of BE-dysplasia and EAC PMID: 26766126

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Subcellular Location
Nucleus, nucleolus.
Protein Families
Universal ribosomal protein uS4 family
Database Links

HGNC: 14497

OMIM: 612980

KEGG: hsa:55272

STRING: 9606.ENSP00000326981

UniGene: Hs.513043

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