Recombinant Human U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3)

Code CSB-YP873661HU
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP873661HU
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP873661HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP873661HU
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP873661HU
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
IMP3
Uniprot No.
Alternative Names
BRMS2; C15orf12; Chromosome 15 open reading frame 12; DKFZp586L0118; FLJ10968; imp3; IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); IMP3_HUMAN; Mitochondrial ribosomal protein S4; MRPS4; OTTHUMP00000183524; U3 small nucleolar ribonucleoprotein protein imp3; U3 snoRNP protein 3 homolog; U3 snoRNP protein imp3
Species
Homo sapiens (Human)
Expression Region
1-184
Target Protein Sequence
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF VTASSFCRRR LPTVLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
Gene References into Functions
  1. our study found that IMP3 expression was higher in the ovarian clear cell carcinoma than the high grade serous and endometrioid subtypes PMID: 29866423
  2. IMP3 expression in uterine leiomyosarcoma could be a marker of a poor prognosis. PMID: 29077232
  3. IMP3 positive pT1 EAC revealed higher levels of lymph node metastases. PMID: 29974234
  4. IMP3 is a strong prognostic factor in non-neuroendocrine brain metastases and in particular in patients with adenocarcinoma metastases.IMP3 expression is associated with poor prognosis in patients with non-small cell lung cancer brain metastases. PMID: 29209838
  5. Study found IMP3 frequently overexpressed in many human neoplasms and show significant associations with adverse tumor features in esophageal adenocarcinomas and cancers of the urinary bladder, lung, stomach, and pancreas. PMID: 29115542
  6. In this study, IMP3 at the nodal site resulted to be associated with low progression-free survival in small-intestine neuroendocrine neoplasms, independently of the Ki-67 index. PMID: 28210937
  7. IMP3 may contribute to the aggressive behavior of metaplastic breast carcinoma , and that this expression could potentially be a prognostic marker PMID: 29146055
  8. These findings suggest that IMP3 expression has prognostic value as a biomarker for chemosensitivity and overall survival in triple negative breast cancer PMID: 28756977
  9. This study establishes p65 as a novel target of IMP3 in increasing glioma cell migration and underscores the significance of IMP3-p65 feedback loop for therapeutic targeting in GBM. PMID: 28465487
  10. IMP3 has a similar specificity, but a better sensitivity, intensity, and extent of reactivity in comparison with AMACR, and may be used as an alternative to AMACR, in support of the diagnosis of BE-dysplasia and EAC PMID: 26766126

Show More

Hide All

Subcellular Location
Nucleus, nucleolus.
Protein Families
Universal ribosomal protein uS4 family
Database Links

HGNC: 14497

OMIM: 612980

KEGG: hsa:55272

STRING: 9606.ENSP00000326981

UniGene: Hs.513043

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1