Human neuromedin U (NMU) ELISA kit

Code CSB-EL015902HU
Size 96T,5×96T,10×96T
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now
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Product Details

Target Name
neuromedin U
Alternative Names
Neuromedin U 25 ELISA Kit; Neuromedin U ELISA Kit; Neuromedin-U-25 ELISA Kit; NmU 25 ELISA Kit; NMU ELISA Kit; NmU-25 ELISA Kit; NMU_HUMAN ELISA Kit
Uniprot No.
Homo sapiens (Human)
Sample Types
serum, plasma, cerebrospinal fluid (CSF), tissue homogenates
Detection Range
0.312 ng/mL-20 ng/mL
0.078 ng/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Assay Principle
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
To assess the linearity of the assay, samples were spiked with high concentrations of Human NMU in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
1:1Average %92
Range %84-98
1:2Average %92
Range %86-98
1:4Average %94
Range %84-98
1:8Average %94
Range %88-98
The recovery of Human NMU spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample TypeAverage % RecoveryRange
Serum (n=5) 9892-102
EDTA plasma (n=4)8884-94
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
202.585 2.387 2.486 2.314
102.058 1.896 1.977 1.805
51.375 1.304 1.340 1.168
2.50.852 0.879 0.866 0.694
1.250.574 0.552 0.563 0.391
0.6250.369 0.384 0.377 0.205
0.3120.271 0.265 0.268 0.096
00.172 0.171 0.172
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

This Human NMU ELISA Kit was designed for the quantitative measurement of Human NMU protein in serum, plasma, cerebrospinal fluid (CSF), tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.312 ng/mL-20 ng/mL and the sensitivity is 0.078 ng/mL.

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Target Background

(From Uniprot)
Ligand for receptors NMUR1 and NMUR2. Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
Gene References into Functions
  1. Results identified NMU as highly expressed in non-small cell lung cancer (NSCLC) tissues and cell lines. Furthermore, integrative bioinformatics analyses demonstrate that NMU may confer the alectinib resistance in NSCLC via multiple mechanisms. PMID: 30096454
  2. NMU might contribute to progression of NMUR2-positive breast cancer PMID: 28423716
  3. The anti-tumorigenic effect of HAND2-AS1 in endometrioid endometrial carcinoma was mediated by down-regulating neuromedin U expression. PMID: 29107108
  4. Results indicate a mechanism of action for neuromedin U (NmU) in HER2-overexpressing breast cancer that enhances resistance to HER2-targeted drugs through conferring cancer stem cell (CSC) characteristics and expansion of the CSC phenotype. PMID: 28340506
  5. This study shows an association between a NMU haplotype and anthropometric indices, mainly linked to fat mass, which appears to be age- and sex-specific in children. PMID: 28235053
  6. Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC. PMID: 27279246
  7. polymorphisms in the gene may be useful in identifying women at risk for osteoporosis. PMID: 25871004
  8. our results defined NmU as a candidate drug response biomarker for HER2-overexpressing cancers and as a candidate therapeutic target to limit metastatic progression and improve the efficacy of HER-targeted drugs. PMID: 24876102
  9. a role for NMU gene through interaction with ADRB2 gene in bone strength regulation PMID: 23936460
  10. Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells. PMID: 21791076
  11. [review] Taken together with its vascular actions, NMU may be a functional link between energy balance and the cardiovascular system and may provide a future target for therapies directed against the disorders that comprise metabolic syndrome. PMID: 19519756
  12. These results suggest that NMU plays a role in feeding behavior and catabolic functions via corticotropin-releasing hormone. PMID: 14623274
  13. NmU expression is related to Myb and that the NmU/NMU1R axis constitutes a previously unknown growth-promoting autocrine loop in myeloid leukemia cells PMID: 15187020
  14. irreversible binding of NmU to its receptors PMID: 15331768
  15. Overexpression of neuromedin U is associated with bladder tumor formation, lung metastasis and cancer cachexia PMID: 16878152
  16. Amino acid variants in NMU associate with overweight and obesity, suggesting that NMU is involved in energy regulation in humans. PMID: 16984985
  17. NMU & its cancer-specific receptors, as well as its target genes, are frequently overexpressed in clinical samples of lung cancer and in cell lines, and that those gene products play indispensable roles in the growth and progression of lung cancer cells. PMID: 17018595
  18. NmU may be involved in the HGF-c-Met paracrine loop regulating cell migration, invasiveness and dissemination of pancreatic ductal adenocarcinoma. PMID: 19118941

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Subcellular Location
Protein Families
NmU family
Tissue Specificity
Expressed throughout the enteric nervous system with highest levels being found in the jejunum.
Database Links

HGNC: 7859

OMIM: 605103

KEGG: hsa:10874

STRING: 9606.ENSP00000264218

UniGene: Hs.418367

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