Human sex hormone-binding globulin,SHBG ELISA Kit

1. SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome PMID: 30046278
2. SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. PMID: 28577342
3. Low SHBG expression not only participates in the development of local insulin resistance, but may also play an important role in PI3K/AKT pathway-mediated systemic insulin resistance and gestational diabetes. PMID: 29298529
4. Fibulin-1 is expressed in breast cancer cell lines, interacts wtih SHBG, and is increased by estradiol PMID: 29940241
5. These data, therefore, reflected that SHBG single nucleotide polymorphism rs6259 causes changes in placental SHBG concentration and may play a functional role in the molecular mechanisms of the gestational diabetes mellitus etiology. PMID: 29484425
6. This is the first study that provides detailed analyses of SHBG with metabolic syndrome components in male diabetic subjects. PMID: 29245159
7. in postmenopausal women, aromatase activity could be an important determinant of skeletal health. PMID: 29329467
8. Consumption of high coffee and caffeine is associated with a reduced risk of low SHBG, an established risk marker for T2DM, which might contribute to the protective effects of coffee for type 2 diabetes. PMID: 28664630
9. Circulating sex steroids, prolactin, insulin-like growth factor (IGF) I, IGF-binding protein 3, and sex hormone-binding globulin (SHBG) were evaluated using backward elimination separately in women pre- and postmenopausal at blood collection. PMID: 28246273
10. Patient-associated features such as body mass index and serum levels of Testosterone and SHBG can improve the predictive capability of consolidate tumor-specific biomarkers in both pre- and postmenopause. PMID: 29474646
11. relationship of testosterone, sex hormone-binding globulin (SHBG), and IGF-1 with bone mineral density (BMD) and bone turnover markers (BTMs) in Korean men, is reported. PMID: 27873076
12. SHBG increased total androgen and estrogen concentrations via hypothalamic-pituitary feedback regulation and prolonged ligand half-life. PMID: 27748448
13. low serum SHBG is associated with insulin resistance in men with nonalcoholic fatty liver disease. PMID: 28282659
14. no association was seen between the stuttering and digit ratio, progesterone, or SHBG PMID: 28992603
15. there is limited clinical utility of serum Estradiol, Testosterone, and SHBG measures for the evaluation of osteoporosis risk in elderly men. PMID: 27753150
16. endogenous steroid hormone, sex hormone-binding globulin, and precursor steroids are associated with hemostatic factors in postmenopausal women PMID: 27797446
17. cross-sectional associations between individual bioavailable sex hormones and SHBG with radiographically assessed kyphosis, were examined. PMID: 27355438
18. Temporal change in serum SHBG, but not Testosterone, Estradiol, or other hormonal variables, was significantly associated with any, nonvertebral or hip fracture incidence in univariable analyses. PMID: 27363725
19. In vitro androgen bioactivity reflects the inhibitory effects of SHBG. PMID: 27576188
20. In men with hepatic steatosis, we found that elevated serum ALT levels were associated with lower serum SHBG levels. PMID: 28540984
21. In the total population adjusting for race/ethnicity, there was no association between SHBG and fracture in women. The interaction between race/ethnicity and SHBG was also not statistically significant. PMID: 28324031
22. Depression and anxiety in subfertile males are associated with lower secretion of SHBG. PMID: 28456148
23. UBQLN4, APP, CTNNB1, SHBG, and COL1A1 might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition PMID: 28796060
24. Male infertility is associated with GA genotype and A allele of rs6259 locus, as well as CC genotype of rs727428 locus in SHBG gene PMID: 28796064
25. Low serum SHBG was the most relevant factor for prediabetes and diabetes PMID: 27583401
26. two non-linked SNPs (rs6259 and rs9901675) at the SHBG gene locus might be of importance for language impairment problems in boys. PMID: 26930261
27. Data suggest there is a strong inverse correlation between SHBG (sex hormone-binding globulin) and DHEA (dehydroepiandrosterone) levels in cord blood obtained at birth from infants of both sexes; there are no associations between SHBG and testosterone or DHT (dihydrotestosterone) levels. This study was conducted in Sweden. PMID: 28373106
28. modulates hepatic lipogenesis; reduction of SHBG plasma levels in obese and type 2 diabetic subjects could be directly associated with nonalcoholic fatty liver disease development through an increase in hepatic lipogenesis PMID: 28359088
29. Short-term weight reduction program (WRP) has the potential effects of lowering body weight, mass index, body fat percentage, and fat weight and increasing serum HDL-C levels and insulin sensitivity in obese children. Although serum SHBG levels moderately increased in both sexes during short-term WRP, change in SHBG concentrations might be a potential biomarker to evaluate improvement in insulin resistance in girls only. PMID: 28489766
30. SHBG was inversely associated with the risk of type 2 diabetes in women. [Meta-Analysis] PMID: 28223343
31. Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. PMID: 27673554
32. Low sex hormone-binding globulin (SHBG) in conjunction with high estradiol has an additive detrimental effect on the risk of type 2 diabetes (T2D) in men. PMID: 26119029
33. we genotyped five hormone-related genes: estrogen receptor-alpha (ESR1), aromatase (CYP19), catechol-O-methyl transferase (COMT), sex hormone-binding globulin (SHBG)and glutathione S-transferase (GSTP1). Our data demonstrate that these ESR1, GSTP1, and CYP19 polymorphisms are associated with risk of BC, and the risk haplotype TGGGGTC could help to identify populations with high susceptibility to BC in Chinese women. PMID: 27323034
34. cortisol/testosterone and cortisol/sex hormone-binding globulin ratios are useful biomarkers for atherosclerosis in middle-age women PMID: 27031578
35. Data show that low that low globulin (GLB) levels were significantly associated with favorable survival, and low ALB levels were associated with a significantly worse survival PMID: 26476541
36. Sex hormone-binding globulin has no effect on salivary testosterone. PMID: 27117450
37. In hormonal contraceptive users, SHBG was positively associated with both activated protein C (APC) resistance and baseline TG, and protein S and prothrombin were important mediators. These data provide further evidence that SHBG may be used as a biomarker in assessing prothrombotic profile of hormonal contraception. PMID: 27323874
38. No significant differences were observed in serum ABP levels in all male farmers between the two groups with different fluoride exposure. These results supported that excess fluoride exposure decreased serum T levels of male farmers with age-specificity. PMID: 27154732
39. results indicated that there was a significant association between migraine and gene-gene interaction among the CYP19A1, FSHR, ESR1 and NRIP1. PMID: 27019440
40. Polymorphisms of SHBG or the neighboring genes were associated with SHBG levels or BMD and osteoporosis PMID: 26657339
41. high SHBG predicts incident clinical and radiographic vertebral fractures in elderly men. PMID: 26391196
42. After early childhood, serum sex hormone-binding globulin declines to a nadir in males at the age of 20 years and remains stable till the sixth decade with a gradual, progressive rise thereafter. In females, the sex hormone-binding globulin nadir is reached earlier with levels rising gradually and progressively with age thereafter and accelerating after the age of 70 years PMID: 26438522
43. higher SHBG (but not testosterone or estradiol) is an independent risk factor for vertebral fractures in older men. PMID: 26778261
44. We found that elevated levels of estradiol and SHBG in HT [Hormone therapy] users were associated with elevated levels of CRP and lower levels of TFPI, both of which may be related to a prothrombotic milieu in HT [Hormone therapy ]users. PMID: 26700933
45. There was a drop in SHBG levels in the first week of smoking cessation and levels continued to remain low. PMID: 26680482
46. SHBG was higher in both obese and non-obese PCOS patients compared to healthy controls. PMID: 26291814
47. Specific SHBG variants affecting serum SHBG levels and SHBG haplotypes are associated with polycystic ovary syndrome, suggesting the role for SHBG as polycystic ovary syndrome candidate gene. PMID: 26600064
48. overlapping of interacting amino acid residues between phthalate compounds and natural ligand, dihydrotestosterone, suggested potential disrupting activity of phthalates in the endocrine homeostasis function of SHBG PMID: 26963243
49. Data suggest that, in endurance runners using endurance training followed by strength training, an initial reduction in testosterone/SHBG ratio is seen after 12 weeks followed by large increase in weeks 12-24 (as compared to endurance training alone). PMID: 25494869
50. SHBG levels were lower in women with polycystic ovary syndrome compared to controls. PMID: 25020276

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HGNC: 10839

OMIM: 182205

KEGG: hsa:6462

STRING: 9606.ENSP00000369816

UniGene: Hs.632235