Mouse Arginase-1(ARG1) ELISA kit

1. Our studies provide proof-of-concept for gene-editing at the Arg1 locus and highlight the challenges that lie ahead to restore sufficient liver-based urea cycle function in patients with urea cycle disorders. PMID: 28566761
2. This study shows for the first time that diabetes-induced increases in arginase 1 expression promotes endothelial cell senescence through the activation of p16INK4A and p53 signaling pathways. PMID: 29673160
3. findings identified a novel function of the VEGFR1 signaling in avoiding over-expression of Arginase 1 potentially to maintain the proper innate immune response. PMID: 29110610
4. Up-regulation of arginase 1 expression/activity in vascular endothelial cells has an integral role in diet-induced cardiovascular dysfunction and metabolic syndrome. PMID: 29048462
5. Complete ablation of Arg1 in the lung affects mRNA abundance of arginine-transporting and -metabolizing genes, and pro-inflammatory genes, but not methacholine responsiveness or accumulation of inflammatory cells. PMID: 29183288
6. Data suggest that Arg1 mRNA and protein expression in liver are significantly higher in obese mice (fed high-fat diet) than in control mice; hepatic Arg1 levels positively correlate with plasma Arg1 levels and negatively correlate with L-arginine bioavailability in plasma. Increased expression of hepatic Arg1 and reduced plasma L-arginine and NO(2)(-) may lead to vascular endothelial dysfunction even in early obesity. PMID: 29098611
7. Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis. PMID: 27432976
8. high-fat/high-sucrose diet-induced visceral adipose tissue inflammation is mediated by endothelial cells-A1 expression/activity. PMID: 28835451
9. Deletion of Arg1 in hematopoietic cells adversely affects blood leukocyte counts and increases foam cell formation. However, no effects on atherosclerosis could be demonstrated, indicating that hematopoietic Arg1 function is not a decisive factor in atherosclerotic plaque formation. PMID: 27998825
10. diabetes-dependent increase in renal arginase-2 expression also requires arginase-1 expression in macrophages PMID: 28446459
11. this study shows that mice lacking Arg1 in macrophages develop increased allergic contact hypersensitivity PMID: 28747341
12. this study shows that Ron is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1 PMID: 27233965
13. Arginase 1 was highly expressed by tumor-associated Gr1+ microglia and macrophages. PMID: 27936099
14. This study uncovers synergistic activation of Arg1 by retinoic acid and IL-4 in M2 macrophages. PMID: 27166374
15. this study shows that group 2 innate lymphoid cells selectively express arginase 1 and that this is critical for their bioenergetics, proliferation and function PMID: 27043409
16. this study shows that c-Jun regulates the activation state of macrophages and promotes arthritis via differentially regulating cyclooxygenase-2 and arginase-1 levels PMID: 28298526
17. deletion or TNF-mediated restriction of Arg1 unleashes the production of nitric oxide by NOS2, which is critical for pathogen control. PMID: 27117406
18. Data indicate that transfected mouse arginase-1 (Arg-I) promotes endothelial senescence and inflammatory responses through eNOS-uncoupling in human umbilical vein endothelial cells (HUVEC cells). PMID: 28153047
19. Arg1 is down-regulated during osteoclast differentiation and may negatively regulate osteoclast differentiation by regulating nitric oxide production. PMID: 26475291
20. Results show that arginase 1 is abundantly present in the bone and bone marrow stromal cells and reveal the role of its deregulation in diabetes-induced bone complications. * HFHS diet induced Arginase activity and expression in bone and bone marrow. PMID: 26704078
21. T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1. PMID: 26491691
22. The production of arginase-1 by tumor cells leads to an ineffective anti-tumor immune response. PMID: 24614600
23. Arg1+ microglia are involved in Abeta plaque reduction during sustained, IL-1beta-dependent neuroinflammation PMID: 26538310
24. findings suggest that increased IL-17A expression by macrophages in E7-expressing skin exposed to DNCB promotes arginase-1 induction and contributes directly to the observed hyperinflammation. PMID: 25720383
25. Arginase 1 is crucially involved in Ang II-induced smooth muscle cell proliferation and arterial fibrosis and stiffness and represents a promising therapeutic target. PMID: 25807386
26. FoxO4 activates Arg1 transcription in endothelial cells in response to MI, leading to downregulation of nitric oxide and upregulation of neutrophil infiltration to the infarct area. PMID: 26438688
27. TAT fused to WW2/WW3 of Smurf2 could interfere with TGF-beta signaling and reduce ArgI gene expression. PMID: 25612247
28. ARG1 activity may participate in the pathogenesis of lymphoproliferative and myeloproliferative disorders. PMID: 26363032
29. data indicate that helminth coinfection induces arginase-1-expressing type 2 granulomas, thereby increasing inflammation and TB disease severity. PMID: 26571397
30. Flow cytometric analysis of intrasplenic leukocytes exposed the presence of a transient population of activated neutrophils that correlated quantitatively with elevated ArgI levels in culture media PMID: 25966956
31. Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection. PMID: 25789453
32. Arg1 expression is decreased, and Arg2 expression is increased in the newborn congenital obstructive nephropathy and in the mouse model. PMID: 25205225
33. Promoter region methylation was decreased at Arg1 in THC-induced myeloid-derived suppressor cells, which then expressed higher Arg1 levels. PMID: 25713087
34. Arg1 plays a central role in the control of TB when NOS2 is rendered ineffective by hypoxia. PMID: 25201986
35. arginase I activity is required for M2 macrophages mediated protection during DSS-induced colitis in PI3Kp110delta-deficient mice. PMID: 25124254
36. the cross talk between HDAC4 and STAT6 is an important regulatory mechanism of Arg1 transcription in dendritic cells PMID: 25332236
37. Diabetic mice exhibit elevated vascular Arg1 and impaired vascular endothelial and nitrergic function. PMID: 23977269
38. A myeloid cell uptake of damaged retinal pigment epithelium or its derivatives as a mechanism generating VEGF (+) Arg-1(+) phenotype in vivo, is demonstrated. PMID: 23977372
39. Our results demonstrate that HPV16.E7 protein enhances drug associated production of arginase-1 by myeloid cells and consequent inflammatory cellular infiltration of skin. PMID: 24732401
40. Reduced arginase-1 activity in Arg1(fl/fl)/Tie2-Cre(tg/-) mice resulted in increased inflammatory response and nitric oxide production by NOS2. PMID: 24465919
41. these data support the notion that PTEN contributes to cell fate decisions of macrophages exemplified by increased Arginase I expression. PMID: 25015834
42. tumor myeloid cells inhibit the adaptive immune response after radiation therapy through expression of the enzyme arginase I PMID: 24992164
43. neither induction of alternative activation nor expression of arginase1 are critical features of disease mediated by attenuated or virulent Francisella species. PMID: 24324751
44. A kinesin heavy chain released by T. brucei induces IL-10 and arginase-1 through SIGN-R1 signaling in myeloid cells, which promotes early trypanosome growth and favors parasite settlement in the host. PMID: 24204274
45. ATRA enhances both Arg-1 and iNOS expression in IFN-gamma-treated DCs, resulting in a tolerogenic phenotype. PMID: 24790153
46. Murine primary macrophages treated with HDL showed increased gene expression for the M2 markers Arginase-1 (Arg-1) and Fizz-1 PMID: 23991225
47. ILC2s are a novel source of Arg1 in resting tissue and during allergic inflammation. PMID: 23924659
48. In preclinical murine models reduced Arg expression directly correlates with delayed healing of skin wounds. PMID: 23552798
49. Our objective was to elucidate mechanisms involved in modulating arginase I induction by IL-4 in murine M2 macrophages PMID: 23913966
50. wall shear stress is a key biomechanical regulator of arginase during atherosclerotic plaque formation and stability PMID: 23390893
51. Diabetes-induced increases in arginase I were involved in the diabetes-induced impairment of retinal blood flow by a mechanism involving vascular endothelial cell dysfunction. PMID: 23232640
52. The consumption of L-arginine by arginase could lead to decreased production of nitric oxide from nitric oxide synthase, contributing to the pathogenesis of the colonic inflammation. PMID: 23215832
53. In a classical model of atherosclerosis, aging induces an increase in level and activity of arginase I in the brains of ApoE-deficient mice. PMID: 22709928
54. Data indicate that purified CD11b(+) cells obtained from the spleen of CpG-ODN+IFA-treated mice exhibited increased arginase (ARG) activity and ARG I expression along with an augmented [(3)H]-L-arginine uptake. PMID: 22083526
55. Arthritogenic alphavirus infection drives a unique myeloid cell activation program in inflamed musculoskeletal tissues that inhibits virus clearance and impedes disease resolution in an arginase 1-dependent manner. PMID: 22972923
56. Data indicate a major for arginase I in diabetes-induced vascular dysfunction. PMID: 22058149
57. Toxoplasma gondii ROP16-dependent arginase-1 induction limits in vivo infection. PMID: 21931552
58. Data show that progesterone not only down-regulates inducible nitric oxide synthase 2 (iNOS) activity in macrophages but also arginase activity. PMID: 21977998
59. These data show that arginase is functional in the cornea and contributes to the immune privilege of the eye, and that modulation of arginase contributes to graft survival. PMID: 21805470
60. These data demonstrate for the first time the role of TLR-4 in mediating the effects of L. mexicana promastigotes on MAP kinase activation, up-regulation of COX-2, iNOS as well as arginase-1 expression in macrophages PMID: 21664694
61. Ron induces Arg1 expression in macrophages through a previously uncharacterized AP-1 site in the Arg1 promoter PMID: 21810604
62. Arg1 is implicated in atherosclerosis regression; LXRalpha is a novel regulator of Arg1 and IRF8 in macrophages. PMID: 21757649
63. enhanced IL-4-Ralpha expression by IL-10 might markedly amplify IL-4-mediated arginase 1 signaling and provide a possible mechanism for synergistic induction of arginase 1 PMID: 21413004
64. Arginase is upregulated following environmental exposures in murine models of asthma, and contributes to the pollution-induced exacerbation of airways responsiveness. PMID: 21291525
65. Mycobacteria-infected macrophages produced soluble factors, including interleukin-6 (IL-6), IL-10, and granulocyte colony-stimulating factor (G-CSF), that induced expression of Arg1 in an autocrine-paracrine manner. PMID: 20716764
66. Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation. PMID: 19713467
67. results suggest that the level of TNF expression determines arginase expression in endothelial cells during myocardial I/R, which is one of the mechanisms by which TNF compromises coronary endothelial function in reperfusion injury PMID: 20091314
68. macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 production PMID: 20483789
69. Increased capacity to upregulate arginase in younger mice results in a more permissive environment for parasite growth, increased disease severity and pathology. PMID: 18478052
70. In a pulmonary schistosomiasis model, Arg-1 expression and activity influence the pathogenesis of granuloma formation and correlate with a Th2 response and maximum egg-induced pathology. PMID: 11714822
71. arginase is involved in muscarinic receptor activation PMID: 12011984
72. Arginase I expression in mouse embryonic development PMID: 12049781
73. Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS) and that requires superoxide and induction by IL-4 for Arg1-dependent suppression of T cell function. PMID: 12496409
74. induced in bleomycin-induced pulmonary fibrosis in mice. PMID: 12679322
75. Gene expression of arginase I and II in pathogenesis of asthma. PMID: 12813022
76. Upon injury, arginase-1 and -2 mRNA, protein, and activity were strongly induced reaching a maximum between day 3 and day 7 postwounding in diabetic mice PMID: 14675208
77. Arginase I mRNA levels and enzyme activity in macrophages from Trypanosoma brucei brucei-infected mice are higher in susceptible BALB/c mice compared with resistant C57BL/6 mice. PMID: 15128819
78. Th2-inducible arginase I expression in macrophages is controlled by an enhancer that lies -3 kb from the basal promoter PMID: 15187136
79. The role of arginase in the Citrobacter rodentium model of colitis was studied. Arginase was induced in the colon during the infection. Arginase is protective by enhancing the generation of polyamines in addition to competitive inhibition of iNOS. PMID: 15265947
80. C/EBPbeta has a key role in the modulation of macrophage arginase I expression in vivo and in vitro PMID: 15665733
81. Elucidation of the mechanisms involved in regulation of arginase I transcription may provide a basis for developing strategies to modulate arginase expression in Th2 cytokine-predominant diseases. PMID: 15922518
82. arginase I induction is a marker of disease in leishmaniasis PMID: 16113329
83. Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. PMID: 16186186
84. upregulation of arginase activity by Th2 cytokines during xenograft rejection limits the bioavailability of L-arginine for the inducible nitric oxide synthase PMID: 16794538
85. suggest an important role for metabolism of l-arginine by arginase I in the modulation of IL-13-induced AHR and identify a potential pathway distal to cytokine receptor interactions for the control of IL-13-mediated bronchoconstriction in asthma. PMID: 17015747
86. Data suggest a regulatory mechanism where NF-kappaB is controlled through arginase-dependent regulation of nitric oxide levels, which may impact on chronic inflammatory diseases that are accompanied by NF-kappaB activation and upregulation of arginases. PMID: 17218616
87. Neither the overexpression nor the deficiency of MKP-1 had any substantial effect on the expression of the arginases. PMID: 17442735
88. cAMP-dependent activation of ARG1 expression is mediated by PKAI and requires histone deacetylation. PMID: 17577214
89. Results suggest that endogenous arginase-derived ornithine may not directly contribute to polyamine homeostasis. PMID: 17686999
90. ArgI is a key marker of the alternative program triggered by PPAR in macrophages. PMID: 18323470
91. The expression of inducible nitric oxide synthase (iNOS) and arginase as markers of classical and alternative activation, respectively, in heart tissue during in vivo Chagas disease are reported. PMID: 18473687
92. Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression PMID: 18824264
93. The blockage and silencing of PD-1, CTLA-4 or both PD-1 and CTLA4 molecules could significantly reduce arginase I activity and expression induced with tumor-associated factor. CD80 deficiency also decreased the arginase I expression and activity. PMID: 18828017
94. Specific elimination of Arg1 in macrophages favored host survival during T. gondii infection and decreased lung bacterial load during tuberculosis infection PMID: 18978793
95. NOS2 knockout mice are more sensitive to ovalbumin-induced airway inflammation and these findings are strongly correlated with increased expression of arginase I/II. PMID: 19027033
96. In the acute murine model of allergic airway inflammation, augmentation of ARG1 expression was similarly the most dramatic change in protein expression; ARG2, NOS1, NOS2, and agmatinase were also increased, whereas NOS3 expression was decreased PMID: 19286931
97. Arg1-expressing macrophages function as suppressors rather than inducers of Th2-dependent inflammation and fibrosis. PMID: 19360123
98. Arginase I played a major role in the suppression of T cell response by regulatory DCs induced by 3LL lung cancer PMID: 19414774
99. these data provide the first evidence that arginase is involved in the pathogenesis of an ocular disease. PMID: 19590038
100. Alternatively-activated macrophages function as suppressor cells by an Arg1 dependent mechanism PMID: 19360123

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KEGG: mmu:11846

STRING: 10090.ENSMUSP00000020161

UniGene: Mm.154144