Mouse Fatty acid synthase(FASN) ELISA kit

1. an unexpected link between FASN and cholesterol synthesis that appears to be required for TLR signal transduction and proinflammatory macrophage activation. PMID: 29463677
2. FASN regulates the pathogenicity of Th17 cells. PMID: 28848043
3. genetic deletion of FASN totally suppresses hepatocarcinogenesis driven by AKT and AKT/c-Met protooncogenes in mice. PMID: 28118080
4. Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states. PMID: 28281280
5. study demonstrates that co-activation of AKT and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN pathway. PMID: 26857837
6. Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. PMID: 26670611
7. These findings suggest that activation of TSHR directly inhibits FASN expression in mature adipocytes, possibly mediated by PKA and ERK PMID: 25655684
8. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis PMID: 25574840
9. FASN plays an important role in exercise-mediated cognitive enhancement, which might be associated to its role in modulating exercise-induced stimulation of neurogenesis. PMID: 24223732
10. FASN is essential for the development, functional competence, and maintenance of the lactating mammary gland. PMID: 24668799
11. Gamma-tocotrienol showed attenuation of triglyceride through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1, stearoyl CoA desaturase 1, and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6 cells. PMID: 23727646
12. Upregulation of host hepatic fatty acid synthase correlates with hepatitis B virus replication. PMID: 23675653
13. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. PMID: 23269672
14. fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult neural stem and progenitor cells and conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis PMID: 23201681
15. Kr-pok (kidney cancer-related POZ domain and Kruppel-like protein) activates transcription of the FASN gene. PMID: 22331133
16. FAS deficiency blocked the generation of palmitoylated Mucin 2, which must be S-palmitoylated at its N terminus for proper secretion and function. PMID: 22341463
17. Fatty acid synthase modulates homeostatic responses to myocardial stress PMID: 21757749
18. These findings pertinent to the etiology of tumor metabolism also underscore the key role of the Sonic hedgehog-->E2F1-->FASN axis in regulating de novo lipid synthesis in cancers. PMID: 20890301
19. Fatty acid synthase may serve as a new diagnostic marker or therapeutic target for the progression of nonalcoholic fatty liver disease PMID: 20606731
20. FAS, which is induced by LXRalpha, may generate regulatory lipids that cause feedback inhibition of LXRalpha in macrophages. PMID: 20479009
21. FAS is present and active in neurons in the hypothalamus PMID: 12376313
22. role in fatty acid synthesis PMID: 12738878
23. fatty acid synthase gene is regulated by SREBP PMID: 12897158
24. Together, these results suggest that FAS generated signals may be essential to support preadipocyte differentiation. PMID: 15707987
25. Insulin acutely reduces hepatic FAS activity by inducing phosphorylation of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its interaction with FAS. PMID: 16054098
26. Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. PMID: 16203972
27. AMP-activated protein kinase-induced Fatty acid synthase phosphorylation inhibits lipogenesis. PMID: 17635921
28. 2 diametrically opposed proteins, fatty acid synthase (induced by feeding) and PPARalpha (induced by starvation), unexpectedly form an integrative sensory module in the central nervous system to orchestrate energy balance PMID: 17694178
29. PPARalpha is required to mediate the response of Scd-1 and Fas gene expression to insulin and that this is normally achieved directly by activation of LXRalpha. PMID: 18079124
30. Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene PMID: 18682402
31. Report effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice. PMID: 18706411
32. FASN activity is essential for B16-F10 melanoma cell proliferation and survival while its inactivation by Orlistat significantly reduces their metastatic spread PMID: 18770866

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KEGG: mmu:14104

STRING: 10090.ENSMUSP00000052872

UniGene: Mm.236443