Mouse Interleukin 27,IL-27 ELISA Kit

1. data suggested that IL-27/IL-27R expression induced by Toxoplasma gondii infection may regulate mast cell-mediated immune response during acute ocular toxoplasmosis in mouse model PMID: 29779048
2. IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review) PMID: 29218601
3. Mechanistic studies have identified that hyperlipidemia induces IL-27 production in a TLR4-dependent manner, likely via downregulating LXR expression in dendritic cells. In this case, mice lacking IL-27 do not develop enhanced antibody responses. PMID: 30037367
4. IFN-gamma induces IL-30 production which suppresses IFN-gamma mediated liver inflammation. PMID: 27721424
5. IL-27 signaling in Foxp3(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system PMID: 28874534
6. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer PMID: 28508429
7. this study has revealed an important role of thymic dendritic cells-derived IL-27 in the regulation of the phenotypic maturation of CD4(+) single positive thymocytes. PMID: 27469302
8. TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response. PMID: 29021521
9. these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1-like cells in celiac disease PMID: 27579860
10. endogenous levels of IL-27 affected the oncogenic properties of mutant p53 in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas. PMID: 26979394
11. Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin. PMID: 28928459
12. Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS injection compared with control specimens. PMID: 27525353
13. these findings highlight critical roles for IFN-gamma and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation PMID: 29167232
14. found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27 PMID: 28953978
15. We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo. PMID: 26982595
16. These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation. PMID: 28835457
17. results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers. PMID: 24443555
18. These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta secretion levels triggered by dual LPS-ATP stimulation. PMID: 28377398
19. findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site PMID: 28062696
20. these data provide the first evidence that IL-27 signals directly to B cells promote GCs and support the role of IL-27 in lupus. PMID: 27619997
21. this study shows that IL-27 plays an important role in immune response and pathogen clearance during infection with Candida parapsilosis PMID: 27259855
22. Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4(+) nTregs by increasing the stability of Foxp3 expression. PMID: 27488350
23. These data provide evidence of a central role of IL-27 for the control of Th2-mediated allergic diseases. PMID: 27799314
24. These data indicate that endogenous IL-27 limits pathology during parainfluenza virus infection PMID: 28129374
25. our data suggest a previously unrecognized role for IL-27 in regulating epithelial cell proliferation and antiviral host defense during the normal wound healing response. PMID: 28132857
26. recombinant IL-30 showed its biological activity by inhibiting Th17 differentiating from naive CD4(+) T cells. Therefore, this method of express and purifying IL-30 provides novel procedures to facilitate structural and functions studies of IL-30. PMID: 26176652
27. An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy. PMID: 26013006
28. IL-27 is one of the limited unique cytokines directly acting on hematopoietic stem cells (HSCs) to promote differentiation into myeloid progenitors during emergency myelopoiesis. PMID: 26991425
29. regulates protective immunity against malaria parasites PMID: 26968425
30. These results provide the first evidences that Fli-1 positively regulates LPS-induced IL-27 production in macrophages PMID: 26900987
31. of autocrine/paracrine mechanisms involving IL-27 in adipocytes under conditions of inflammatory stress that may link obesity with inflammatory diseases. PMID: 26638127
32. Increased IL-27 expression in bleomycin-induced pulmonary fibrosis was noted. PMID: 25888222
33. IL-27 induces the endothelial differentiation in cardiac resident stem cells through STAT3/Pim-1 signaling pathway. PMID: 26142823
34. demonstrate that suppression mediated by interferon and IL-27 is a negative feedback mechanism for group 2 innate lymphoid cells function in vivo PMID: 26595888
35. Natural killer cells-dendritic cells interaction elicits a positive feedback loop for IFN-gamma and IL-27 production. PMID: 26347474
36. demonstrate the essential role of IL-27 signaling in regulating immune responses to extracellular protozoan infections PMID: 26222157
37. IL-27 regulates enhanced susceptibility to S. aureus pneumonia following influenza infection, potentially through the induction of IL-10 and suppression of IL-17. PMID: 25651926
38. Importance of IL-27 for the physiological control of immunopathology and the potential value of well-timed IL-27 application to treat life-threatening inflammation during lung infection. PMID: 24809349
39. Most innate immune receptor agonist-based vaccine adjuvants need IL-27 for CD4 and CD8 responses. IL-27 dependency is T-cell-intrinsic, requiring T-cell expression of IL-27Ralpha. It is critical high-affinity T-cell response to subunit immunization. PMID: 25267651
40. Our study has identified a novel proinflammatory role for IL-27 in vivo that promotes Th17 differentiation by inducing Th17-supporting cytokines in APCs. PMID: 24129161
41. IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses. PMID: 24021664
42. Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-gamma for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages. PMID: 25187652
43. IL-27/WSX-1 regulated PGE2 secretion via STAT1-COX-2 pathway in macrophages and affected helper T cell response in a PGE2-mediated fashion. PMID: 25088998
44. In conclusion, it is suggested that IL-27 may possibly act as an anti-inflammatory cytokine during malaria. PMID: 24522137
45. IL-27 plays a critical role in the parent-to-F1 model of acute graft versus host disease and that blocking IL-27 could have therapeutic relevance PMID: 24700119
46. this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27. PMID: 24604832
47. these data demonstrate that in contrast to viral infections at other sites, IL-27 does not play a proinflammatory role during JHMV-induced encephalomyelitis. PMID: 24890725
48. IL-27 production by CD11c(+) cells was inhibited. PMID: 24337375
49. the findings from the past decade identify IL-27 as a critical immunoregulatory cytokine, especially for T cells, whereas some controversy is fueled by results challenging the view of IL-27 as a classical silencer of inflammation. PMID: 23904441
50. IL-27 suppresses the production of IFN-gamma by CD4+ T cells during blood stage malaria infection by preventing the development of terminally differentiated Th1 cells specifically by restricting IL-12 signals. PMID: 23593003

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KEGG: mmu:246779

STRING: 10090.ENSMUSP00000054637

UniGene: Mm.222632