IL27

The gene IL27 encodes for interleukin-27 (IL-27), a heterodimeric cytokine composed of Ebi3 and p28 subunits. Commonly known as a member of the IL-12 family, IL-27 plays a crucial role in innate and adaptive immunity. It binds to the IL-27Rα or gp130 receptor, triggering signaling pathways including JAK/STAT, MAPK, and NF-κB. IL-27 exhibits both pro-inflammatory and anti-inflammatory properties, influencing immune cell function and cytokine production. It is involved in various diseases, such as autoimmune disorders, infectious diseases, and cancer. Research on IL-27 inhibitors has shown potential for therapeutic applications, targeting immune dysregulation and inflammation.