Mouse Osteoclast-associated immunoglobulin-like receptor(OSCAR) ELISA kit

Code CSB-EL017255MO
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
osteoclast associated, immunoglobulin-like receptor
Alternative Names
Oscar ELISA Kit; Osteoclast-associated immunoglobulin-like receptor ELISA Kit; Osteoclast-associated receptor ELISA Kit; mOSCAR ELISA Kit; Ocl178 ELISA Kit
Uniprot No.
Mus musculus (Mouse)
Sample Types
serum, plasma, tissue homogenates
Detection Range
37.5 pg/mL-2400 pg/mL
9.375 pg/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Assay Principle
Intra-assay Precision (Precision within an assay): CV%<8%      
Three samples of known concentration were tested twenty times on one plate to assess.  
Inter-assay Precision (Precision between assays): CV%<10%      
Three samples of known concentration were tested in twenty assays to assess.    
To assess the linearity of the assay, samples were spiked with high concentrations of mouse OSCAR in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
  Sample Serum(n=4)  
1:5 Average % 89  
Range % 82-93  
1:10 Average % 105  
Range % 97-108  
1:20 Average % 93  
Range % 88-97  
1:40 Average % 95  
Range % 91-98  
The recovery of mouse OSCAR spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type Average % Recovery Range  
Serum (n=5) 94 89-97  
EDTA plasma (n=4) 91 85-94  
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
pg/ml OD1 OD2 Average Corrected  
2400 2.885 2.877 2.881 2.761  
1200 2.068 2.089 2.079 1.959  
600 1.152 1.123 1.138 1.018  
300 0.689 0.687 0.688 0.568  
150 0.398 0.391 0.395 0.275  
75 0.301 0.289 0.295 0.175  
37.5 0.210 0.222 0.216 0.096  
0 0.119 0.121 0.120    
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

The Mouse Osteoclast-associated immunoglobulin-like receptor (OSCAR) ELISA kit is a reliable and accurate tool for the detection of OSCAR protein levels in mouse serum, plasma, and tissue homogenates. OSCAR is a type I transmembrane protein that is predominantly expressed on osteoclasts and plays a crucial role in bone resorption.

The Mouse OSCAR ELISA kit has a wide detection range of 37.5 pg/mL-2400 pg/mL and a high sensitivity of 9.375 pg/mL, ensuring precise and accurate measurements even at low concentrations. The kit uses a sandwich assay principle, which involves the use of two monoclonal antibodies specific to the mOSCAR protein.

The assay time for the kit is 1-5 hours, and the sample volume required is 50-100ul. Detection is done at a wavelength of 450 nm, making it easy to read and interpret the results. The kit is suitable for use in immunology research, where OSCAR protein levels are of interest, and has been cited in over 2 research articles.

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Target Background

(From Uniprot)
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
Gene References into Functions
  1. OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis PMID: 23817038
  2. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID: 21841309
  3. PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade. PMID: 12695521
  4. the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation PMID: 15184345
  5. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts PMID: 16109714
  6. Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis. PMID: 18762192

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
Tissue Specificity
Specifically expressed in preosteoclasts or mature osteoclasts.
Database Links
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