Mouse Secreted frizzled-related protein 3(FRZB) ELISA kit

1. particle-induced inhibition on cell proliferation, differentiation and FRZB expression were all reversed by miR-130b silence PMID: 28382864
2. Stable overexpression of Frzb in MC3T3-E1 cells increased calcium deposition and osteoblast markers compared with control. Western blot analysis showed that the increased osteogenesis was associated with reduced canonical, but increased non-canonical Wnt signaling. PMID: 26927515
3. an inverse septal-to-temporal increase in the expression of sfrp3 that emerges during postnatal development, is reported. PMID: 26337530
4. The spatiotemporally dynamic expression ofsFRP3 strongly suggests that sFRP3 has potential functions in the sensory neuron genesis and sensory circuitry formation. PMID: 23827310
5. Our results suggest that FrzB may have a protective role on cartilage degradation and matrix metalloproteinase induction in mouse chondrocytes PMID: 24984954
6. left ventricles from post-MI mice showed an increased sFRP3 mRNA level, particularly in cardiac fibroblasts, and (iv) mechanical stretch enhanced sFRP3 expression and release in myocardial fibroblasts PMID: 24330105
7. Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice. PMID: 23207650
8. Study identifies sFRP3 as an inhibitory niche factor from local mature dentate granule neurons that regulates multiple phases of adult hippocampal neurogenesis. PMID: 23395446
9. Data indicate an important role for frizzled-related protein (Frzb) in joint homeostasis and highlight the complex biology of WNT signaling in the joint. PMID: 22264237
10. Secreted Frizzled-related proteins (sFrps) are expressed in the postnatal cerebral cortex in regional and lamina patterns in the major subdivisions of the cerebral cortex: the olfactory bulb, the hippocampal formation, and the neocortex. PMID: 15116386
11. sFRP3 may stimulate differentiation through a beta-catenin-independent pathway in addition to its previously known function as a decoy receptor for Wnt's PMID: 15312239
12. Loss of Frzb may contribute to cartilage damage by increasing the expression and activity of MMPs, in a WNT-dependent and WNT-independent manner. This may contribute to the development of osteoarthritis. PMID: 18050203
13. Our findings support Wnt5a and sfrp3 as regulators of otic capsule formation in the developing mouse inner ear. PMID: 18991062

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KEGG: mmu:20378

STRING: 10090.ENSMUSP00000028389

UniGene: Mm.427436