Angiotensin II is a potent vasoactive peptide hormone that plays a central role in the renin-angiotensin-aldosterone system, regulating blood pressure, fluid balance, and cardiovascular homeostasis. Angiotensin-converting enzyme cleaves angiotensin I to produce this octapeptide hormone. It exerts its biological effects primarily through binding to angiotensin II type 1 and type 2 receptors. Beyond its cardiovascular functions, angiotensin II influences aldosterone secretion and sympathetic nervous system activity. Researchers have linked it to various pathological processes including hypertension, heart failure, and renal disease.
The Mouse angiotensin II ELISA Kit (CSB-E04495m) provides quantitative measurement of angiotensin II in mouse samples using a sandwich assay principle. This kit works with multiple sample types including serum, plasma, cell culture supernatants, and tissue homogenates. The detection range spans 0.45-30 pg/mL with sensitivity of 0.11 pg/mL. The assay requires 50-100 μL sample volume and completes within 1-5 hours. Detection occurs at 450 nm wavelength for reliable quantification of this important vasoactive peptide in Mus musculus specimens.
Application Examples
Note: The following application examples are drawn from a selection of publications citing this product. For additional applications, please refer to the full list of references in the "Citations" section.
Based on the provided information, no published research applications were found for this mouse angiotensin ELISA kit in the available literature excerpts.
• Cardiovascular research - Potential applications in studies examining the renin-angiotensin system and blood pressure regulation in mouse models
• Renal physiology - Possible use in research examining kidney function and fluid balance mechanisms
• Endocrine studies - Applications may include research on hormonal regulation and metabolic pathways involving the angiotensin system
• Disease modeling - Potential use in mouse models of hypertension, cardiovascular disease, and related pathological conditions
