Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit

Code CSB-EL001441RA
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
advanced glycosylation end product-specific receptor
Alternative Names
Ager ELISA Kit; Rage ELISA Kit; Advanced glycosylation end product-specific receptor ELISA Kit; Receptor for advanced glycosylation end products ELISA Kit
Abbreviation
AGER
Uniprot No.
Species
Rattus norvegicus (Rat)
Sample Types
serum, plasma,tissue homogenates
Detection Range
31.25 pg/mL-2000 pg/mL
Sensitivity
7.81 pg/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Immunology
Assay Principle
quantitative
Measurement
Sandwich
Precision

Linearity

Recovery

Typical Data

Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Rat Advanced glycosylation end product-specific receptor (AGER) ELISA kit is a powerful tool for researchers in the field of immunology. It allows for the accurate and reliable quantification of Rat AGER levels in serum, plasma, and tissue homogenates.

It is designed for quick and easy detection of AGER in Rat samples, and has a wide detection range of 31.25 pg/mL to 2000 pg/mL, with a sensitivity of 7.81 pg/mL. The assay time is only 1-5 hours, and the sample volume required is just 50-100ul, making it an ideal choice for high-throughput screening.

The kit uses a sandwich assay principle for quantitative measurement of Rat AGER levels, and it can be read using a standard 450 nm wavelength detector. The kit can be used in a research setting and is suitable for a variety of applications within the field of immunology. By accurately measuring AGER levels, researchers can gain valuable insights into the role of this protein in immune system function and disease.

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Target Background

Function
(From Uniprot)
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Endothelial cells and cardiomyocytes.
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