Name: Rat Protein S100-A8(S100A8) ELISA kit
Brand: CUSABIO
SKU: CSB-EL020641RA

Product Details

Target Name	S100 calcium binding protein A8
Alternative Names	S100a8 ELISA Kit; Mrp8 ELISA Kit; Protein S100-A8 ELISA Kit; Calgranulin-A ELISA Kit; Migration inhibitory factor-related protein 8 ELISA Kit; MRP-8 ELISA Kit; p8 ELISA Kit; S100 calcium-binding protein A8 ELISA Kit
Abbreviation	S100A8
Uniprot No.	P50115
Species	Rattus norvegicus (Rat)
Sample Types	serum, plasma, tissue homogenates
Detection Range	3.12 ng/mL-200 ng/mL
Sensitivity	0.78 ng/mL
Assay Time	1-5h
Sample Volume	50-100ul
Detection Wavelength	450 nm
Research Area	Others
Assay Principle	quantitative
Measurement	Sandwich
Troubleshooting and FAQs	ELISA kit FAQs
Storage	Store at 2-8°C. Please refer to protocol.
Lead Time	5-7 working days

Q&A and Customer Reviews

■ Q&A

Per customers request, please provide the following information regarding Rat Protein S100-A8, S100A8 ELISA Kit (CSB-EL020641RA):
1) What is the Uniprot/Accession number that this kit is designed for? Is the kit designed for XYZ species or is it designed for a different species such as Human and cross reacts with XYZ species?
2) Is the capture antibody a monoclonal or polyclonal?
3) What is the host of the capture antibody?
4) What’s the immunogen or immunogen range of the capture antibody?
5) What’s is the species of the immunogen of the capture antibody, human or something else?
6) Is the detection antibody a monoclonal or polyclonal?
7) What is the host of the detection antibody?
8) What is the immunogen or immunogen range of the detection antibody?
9) What is the species of the immunogen of the detection antibody? Human or something else?
10) What’s is that standard? A recombinant protein or something else? If a recombinant protein, what is the host?
11) If recombinant protein, is it full length or partial?
12) What is the species of the standard– human or something else?
13) What sample type was tested with this kit (serum? plasma? Something else?) and what were the reference values.

Thanks for your inquiry!
CSB-EL020641RA
This kit is designed according to: https://www.uniprot.org/uniprot/P50115.
Capture antibody is mouse monoclonal antibody and immunogen is NS0-derived recombinant protein, full length.
Detection antibody is goat polyclonal antibody and immunogen is NS0-derived recombinant protein, partial.
Standard is NS0-derived recombinant protein.
This kit is designed for rat. Although it has homology with the protein from other species, we don't suggest you use this kit to test other species because there is matrix interference.
We tested serum and plasma samples before and the test value is ND--12.5ng/ml.
Pls let me know if you have any further questions. Thank you.

■ Customer Reviews

Target Data

Function	S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include
Gene References into Functions	Establish S100A8 transgenic rats to elucidate role as a regulator in acute inflammation. PMID: 28913572 Recombinant rat r-S100A8 bound to r-CD68. The expression levels of S100A8 were significantly suppressed after the macrophages had been treated with an anti-CD68 antibody. Small interfering CD68 also significantly suppressed activation of macrophages through an autocrine pathway by r-S100A8. PMID: 27312849 results support S100A8 as a novel therapeutic target to control ASM contraction in asthma PMID: 28088518 vagus nerve electrical stimulation may produce a protective effect on septic shock in rats by decreasing the production of S100A8. PMID: 27035526 Expression of S100A8 mRNA and the corresponding protein in cultured NRVCs was similar between control cells and norepinephrine-stimulated cells, but was markedly upregulated at 12 hours after the withdrawal of NE. PMID: 25820336 Mrp8 may potentiate the perpetuation of mesial temporal lobe epilepsy by activating the NF-kappaB pathway in astrocytes. PMID: 23982744 Report role for MRP8 for exaggerated in-stent restenosis in diabetes mellitus type 2. PMID: 22381691 In vivo zinc regulates S100A8 expression and modulates the link between S100A8-RAGE interaction and downstream nuclear factor kappaBeta/COX-2 signaling PMID: 19111725 The bladder uroepithelium was a prominent cell source of S100A8-S100A9 in animals with complicated urinary tract infection, which was not detected in animals with asymptomatic urinary tract infection. PMID: 19667050 Show More Hide All
Subcellular Location	Secreted, Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Peripheral membrane protein
Protein Families	S-100 family
Database Links	KEGG: rno:116547 STRING: 10116.ENSRNOP00000015473 UniGene: Rn.31839

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Rat Protein S100-A8(S100A8) ELISA kit

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Code	CSB-EL020641RA
Size	96T,5×96T,10×96T
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