S100A8

S100A8, also known as calgranulin A or myeloid-related protein 8 (MRP8), is a calcium-binding protein belonging to the S100 family. It forms a heterodimer with S100A9, which is involved in regulating inflammation and immune responses. The S100A8/A9 complex can bind to receptors like RAGE, triggering intracellular signaling pathways such as NF-κB.
S100A8 is associated with various diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. Elevated levels of S100A8 are often found in patients with these conditions. Currently, there are ongoing efforts in drug development to target S100A8 and its signaling pathways, aiming to alleviate inflammation and treat related diseases.