Product Details

Full Product Name

Rabbit anti-Rattus norvegicus (Rat) S100a8 Polyclonal antibody

Uniprot No.

P50115

Target Names

S100a8

Alternative Names

S100a8 antibody; Mrp8 antibody; Protein S100-A8 antibody; Calgranulin-A antibody; Migration inhibitory factor-related protein 8 antibody; MRP-8 antibody; p8 antibody; S100 calcium-binding protein A8 antibody

Raised in

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant Rat Protein S100-A8 protein (2-89AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function	S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include
Gene References into Functions	Establish S100A8 transgenic rats to elucidate role as a regulator in acute inflammation. PMID: 28913572 Recombinant rat r-S100A8 bound to r-CD68. The expression levels of S100A8 were significantly suppressed after the macrophages had been treated with an anti-CD68 antibody. Small interfering CD68 also significantly suppressed activation of macrophages through an autocrine pathway by r-S100A8. PMID: 27312849 results support S100A8 as a novel therapeutic target to control ASM contraction in asthma PMID: 28088518 vagus nerve electrical stimulation may produce a protective effect on septic shock in rats by decreasing the production of S100A8. PMID: 27035526 Expression of S100A8 mRNA and the corresponding protein in cultured NRVCs was similar between control cells and norepinephrine-stimulated cells, but was markedly upregulated at 12 hours after the withdrawal of NE. PMID: 25820336 Mrp8 may potentiate the perpetuation of mesial temporal lobe epilepsy by activating the NF-kappaB pathway in astrocytes. PMID: 23982744 Report role for MRP8 for exaggerated in-stent restenosis in diabetes mellitus type 2. PMID: 22381691 In vivo zinc regulates S100A8 expression and modulates the link between S100A8-RAGE interaction and downstream nuclear factor kappaBeta/COX-2 signaling PMID: 19111725 The bladder uroepithelium was a prominent cell source of S100A8-S100A9 in animals with complicated urinary tract infection, which was not detected in animals with asymptomatic urinary tract infection. PMID: 19667050 Show More Hide All
Subcellular Location	Secreted, Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Peripheral membrane protein
Protein Families	S-100 family
Database Links	KEGG: rno:116547 STRING: 10116.ENSRNOP00000015473 UniGene: Rn.31839

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Check Code：

Code	CSB-PA020641LA01RA
Size	US$299
Image	Western Blot Positive WB detected in: Rat spleen tissue, Rat lung tissue All lanes: S100a8 antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 11 kDa Observed band size: 11 kDa
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S100a8 Antibody

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