Rat matrix metallopeptidase 8 (neutrophil collagenase) (MMP8) ELISA kit

1. Simvastatin significantly blocked cigarette smoke induced up-regulation of MMP-8 and -9, but had no effect on MMP-12, TIMP-1 and TIMP-4 expression in rat COPD model. PMID: 28260878
2. Study showed that E. faecalis strains ATCC 29212 or ATCC 700802 could induce local IL-1beta and MMP-8 expression in persistent apical periodontitis; compared with noncytolytic E. faecalis, cytolytic E. faecalis may cause more severe local inflammation and tissue destruction PMID: 26055433
3. hydrogen sulfide downregulated protein and mRNA expression of MMP-8, MMP-13, and TIMP-1 in rats with volume overload; this effect might be involved in the amelioration of ventricular structural remodeling and cardiac function PMID: 23974514
4. MMP-8, MMP-9 and MMP-12 gene and protein expression increased profoundly (p < 0.01), and MMP-13 mRNA and MMP-2 mRNA and protein modestly (p < 0.001) in the anastomoses. PMID: 23619615
5. Elevated levels of MMP-8 in CSF were found following spinal cord injury. PMID: 22687332
6. Mmp8/14 expression seem important in the tissue destruction during periodontal disease in type 1 diabetes. PMID: 21826658
7. These results demonstrate that superphysiologic levels of the proteinase MMP-8 can result in decreased collagen and lead to impaired wound healing. PMID: 21875735
8. MMP-8 is involved in sensory nerve growth within the interstitial CoL matrix through modulation by the axonal guidance molecules and/or extracellular matrix components PMID: 21697883
9. related to the development of periradicular lesions PMID: 21447140
10. Venous pressure elevation (induced by acute venular occlusion) increases MMP-1, MMP-9, and MMP-8 enzymatic activity which may contribute to inflammation and endothelial dysfunction associated with this disease by influencing critical surface receptors. PMID: 20923679
11. MMP-2 and MMP-8 cooperate to degrade the cervical fibers, leading to cervical softening and expansion. PMID: 19923067
12. Ibuprofen upregulates the expressions of collagenases including MMP-1, -8, -9, and -13. PMID: 19847888
13. These results indicate that bradykinin at reperfusion triggers its cardioprotective signalling pathway through MMP-8-dependent transactivation of the EGFR. PMID: 19583703
14. Results suggest that matrix metalloproteinase (MMP)-13, but not MMP-8 or TIMP-1, plays an important role in estrogen deficiency-induced bone loss. PMID: 15609084
15. secretion of MMP-8 by neutrophils may play a critical role in resolving the fibrotic scar generated during cholestasis PMID: 16153442
16. Osteoblasts and osteocytes may play a role in the remodeling of extracellular matrices with MMP8 during healing of a defect in bone. PMID: 18615687
17. Expression of metalloproteinase-8 and -13 on articular cartilage is increased in a rat immobilized knee model. PMID: 19346731

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KEGG: rno:63849

STRING: 10116.ENSRNOP00000013936

UniGene: Rn.44474